老年患者的肌萎缩性肥胖和高血压:病理生理学和管理策略的叙述性综述。

IF 1.1 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Mihaela Jurdana, Lovro Žiberna
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引用次数: 0

摘要

引言:由于人口的逐渐老龄化以及肥胖和缺乏体育活动的日益普遍,非典型性肥胖和高血压是一个全球范围内日益严重的公共卫生问题。肌细胞型肥胖的特点是同时存在肌细胞减少症(肌肉量减少)和肥胖症(脂肪量增加)。由于症状不具体,肌肉萎缩性肥胖在很大程度上仍未得到诊断。这篇综述探讨了肌萎缩性肥胖及其与高血压的关系的最新研究,重点是动脉硬化。方法:通过系统检索PubMed和Scopus数据库中的相关科学文献,进行全面的叙述性综述。结果:肌肉型肥胖和高血压密切相关,共有炎症、胰岛素抵抗和氧化应激等共同因素,动脉硬化起着至关重要的作用。讨论:鉴于肌萎缩性肥胖缺乏特定症状,早期诊断和治疗至关重要。治疗策略应优先考虑减肥、充足的蛋白质摄入和有规律的体育活动。需要对药物干预措施进行进一步研究。结论:全身性肥胖和高血压对全球公共卫生提出了重大挑战。解决动脉硬化症是有效管理这些疾病的关键。生活方式的改变,包括体重管理和体育活动,仍然是治疗肌萎缩性肥胖的核心,同时还需要更多的研究来探索潜在的药物选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sarcopenic obesity and hypertension in elderly patients: a narrative review of pathophysiology and management strategies.

Introduction: Sarcopenic obesity and hypertension are a public health problem that is increasing worldwide due to the progressive aging of the population and the increasing prevalence of obesity and physical inactivity. Sarcopenic obesity is characterized by the simultaneous presence of sarcopenia (loss of muscle mass) and adiposity (increase in fat mass). Because symptoms are not specific, sarcopenic obesity remains largely undiagnosed. This review explores the latest research on sarcopenic obesity and its association with hypertension, with a focus on arterial stiffness.

Methods: A comprehensive narrative review was conducted by systematically searching PubMed and Scopus databases for relevant scientific literature.

Results: Sarcopenic obesity and hypertension are closely linked, sharing common factors such as inflammation, insulin resistance, and oxidative stress, with arterial stiffness playing a crucial role.

Discussion: Given the lack of specific symptoms for sarcopenic obesity, early diagnosis and management are crucial. Treatment strategies should prioritize weight loss, adequate protein intake, and regular physical activity. Further investigation is warranted for pharmacological interventions.

Conclusion: Sarcopenic obesity and hypertension present significant challenges to global public health. Addressing arterial stiffness is paramount in managing these conditions effectively. Lifestyle modifications, including weight management and physical activity, remain central to the treatment of sarcopenic obesity, while additional research is needed to explore potential pharmacological options.

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来源期刊
Annali dell'Istituto superiore di sanita
Annali dell'Istituto superiore di sanita PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
3.80
自引率
4.80%
发文量
65
审稿时长
>12 weeks
期刊介绍: Annali dell’Istituto Superiore di Sanità is a peer reviewed quarterly science journal which publishes research articles in biomedicine, translational research and in many other disciplines of the health sciences. The journal includes the following material: original articles, reviews, commentaries, editorials, brief and technical notes, book reviews. The publication of Monographic Sections has been discontinued. In case you wish to present a small number of coordinated contributions on specific themes concerning priorities in public health, please contact the Editorial office. The journal is in English.
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