针对滤泡性淋巴瘤的个体化治疗——是否正在转向?

IF 3.3 4区医学 Q2 HEMATOLOGY

Hematological Oncology Pub Date : 2023-07-22 DOI:10.1002/hon.3205

Kim M Linton, Lena Specht, Astrid Pavlovsky, Carrie A Thompson, Eva Kimby, Daphne de Jong, Loretta J Nastoupil, Anne-Ségolène Cottereau, Carla Casulo, Clémentine Sarkozy, Jessica Okosun

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引用次数: 0

摘要

滤泡性淋巴瘤是最常见的惰性淋巴瘤，约占西方国家所有新诊断的非霍奇金淋巴瘤的20%-25%。虽然结果大多是有利的，但临床表型谱包括结果明显较差的高危人群。这篇综述讨论了最近的风险分层和治疗方法的更新，从有限和晚期滤泡性淋巴瘤的前期治疗到复发、难治性疾病的越来越多的选择，以及如何从个性化的角度来看待这一问题。在如何根据不同的风险精确和前瞻性地为患者选择最佳治疗方法方面仍然存在显著的差距，人们期望对这些不同表型的生物学理解的增加以及基于成像和生物标志物的工具的不断改进将及时消除这些差距。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Personalised therapy in follicular lymphoma - is the dial turning?

Follicular lymphoma is the most common indolent lymphoma accounting for approximately 20%-25% of all new non-Hodgkin lymphoma diagnoses in western countries. Whilst outcomes are mostly favorable, the spectrum of clinical phenotypes includes high-risk groups with significantly inferior outcomes. This review discusses recent updates in risk stratification and treatment approaches from upfront treatment for limited and advanced stage follicular lymphoma to the growing options for relapsed, refractory disease with perspectives on how to approach this from a personalized lens. Notable gaps remain on how one can precisely and prospectively select optimal treatment for patients based on varying risks, with an anticipation that an increased understanding of the biology of these different phenotypes and increasing refinement of imaging- and biomarker-based tools will, in time, allow these gaps to be closed.

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来源期刊

Hematological Oncology 医学-血液学

CiteScore

4.20

自引率

6.10%

发文量

147

审稿时长

>12 weeks

期刊介绍： Hematological Oncology considers for publication articles dealing with experimental and clinical aspects of neoplastic diseases of the hemopoietic and lymphoid systems and relevant related matters. Translational studies applying basic science to clinical issues are particularly welcomed. Manuscripts dealing with the following areas are encouraged: -Clinical practice and management of hematological neoplasia, including: acute and chronic leukemias, malignant lymphomas, myeloproliferative disorders -Diagnostic investigations, including imaging and laboratory assays -Epidemiology, pathology and pathobiology of hematological neoplasia of hematological diseases -Therapeutic issues including Phase 1, 2 or 3 trials as well as allogeneic and autologous stem cell transplantation studies -Aspects of the cell biology, molecular biology, molecular genetics and cytogenetics of normal or diseased hematopoeisis and lymphopoiesis, including stem cells and cytokines and other regulatory systems. Concise, topical review material is welcomed, especially if it makes new concepts and ideas accessible to a wider community. Proposals for review material may be discussed with the Editor-in-Chief. Collections of case material and case reports will be considered only if they have broader scientific or clinical relevance.