日本DS-1样G2P[4]a组轮状病毒的全基因组测序和基因组特征。

IF 1.9 4区医学 Q3 GENETICS & HEREDITY

Virus Genes Pub Date : 2023-10-01 Epub Date: 2023-07-05 DOI:10.1007/s11262-023-02018-7

Tung Phan, Toshiyuki Hikita, Shoko Okitsu, Yuki Akari, Satoshi Komoto, Satoshi Hayakawa, Hiroshi Ushijima

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引用次数: 0

摘要

1973年轮状病毒被发现后，它成为世界范围内引起人类急性肠胃炎的主要病原体。在这项研究中，我们对一名完全接种Rotarix®疫苗的日本急性肠胃炎儿童的粪便中DS-1样G2P[4]a组轮状病毒进行了全基因组测序和基因组表征。基因组研究确定了该轮状病毒株的基因组群G2-P[4]-I2-R2-C2-M2-A2-N2-T2-E2-H2。其VP7和VP4蛋白的抗原表位与疫苗株相比有显著的错配。我们的研究是研究日本新出现的G2P[4]轮状病毒VP7和VP4基因进化的最新尝试。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Whole genome sequencing and genomic characterization of a DS-1-like G2P[4] group A rotavirus in Japan.

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Whole genome sequencing and genomic characterization of a DS-1-like G2P[4] group A rotavirus in Japan.

After rotavirus was discovered in 1973, it became the leading pathogen in causing acute gastroenteritis in humans worldwide. In this study, we performed whole genome sequencing and genomic characterization of a DS-1-like G2P[4] group A rotavirus in feces of a Japanese child with acute gastroenteritis who was fully Rotarix® vaccinated. The genomic investigation determined a genomic constellation G2-P[4]-I2-R2-C2-M2-A2-N2-T2-E2-H2 of this rotavirus strain. Its antigenic epitopes of the VP7 and VP4 proteins had significant mismatches compared with the vaccine strains. Our study is the latest attempt to investigate the evolution of the VP7 and VP4 genes of emerging G2P[4] rotavirus in Japan.

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来源期刊

Virus Genes 医学-病毒学

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Viruses are convenient models for the elucidation of life processes. The study of viruses is again on the cutting edge of biological sciences: systems biology, genomics, proteomics, metagenomics, using the newest most powerful tools. Huge amounts of new details on virus interactions with the cell, other pathogens and the hosts – animal (including human), insect, fungal, plant, bacterial, and archaeal - and their role in infection and disease are forthcoming in perplexing details requiring analysis and comments. Virus Genes is dedicated to the publication of studies on the structure and function of viruses and their genes, the molecular and systems interactions with the host and all applications derived thereof, providing a forum for the analysis of data and discussion of its implications, and the development of new hypotheses.