一个有希望的治疗自发性卵巢过度刺激综合征由于家族性部分脂肪营养不良:GnRH类似物联合囊肿抽吸。

IF 2.4 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Asena Gökçay Canpolat, Batuhan Aslan, Yavuz Emre Şükür
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引用次数: 0

摘要

目的:介绍一例家族性部分脂肪营养不良(FPLD)合并多囊卵巢综合征(PCOS)合并自发性卵巢过度刺激综合征(OHSS)样卵巢极度增大的患者,经促性腺激素释放激素类似物联合腹腔囊肿抽吸治疗成功。方法:本文报告1例FPLD合并PCOS患者的描述性病例。结果:治疗后6个月临床改善,总睾酮和DHEAS水平逐渐降低。此外,高胰岛素血症和高甘油三酯血症也有显著改善。此外,还观察到卵巢囊肿的大小缩小,黑棘皮病的大小和定位数量减少,mFGS评分降低,体重减轻。结论:虽然文献中很少有报道描述PCOS与FPLD之间的关系,但这种新型自发性ohss样疾病的管理尚未明确定义。在多囊卵巢极度增大和严重的高雄激素血症的情况下,GnRH类似物可以考虑防止卵巢增大和减少高雄激素血症,特别是当其他治疗方案不合适时。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A promising treatment for spontaneous ovarian hyperstimulation syndrome due to familial partial lipodystrophy: GnRH analogs combined with cyst aspiration.

A promising treatment for spontaneous ovarian hyperstimulation syndrome due to familial partial lipodystrophy: GnRH analogs combined with cyst aspiration.

Purpose: To present a patient with familial partial lipodystrophy (FPLD) and polycystic ovary syndrome (PCOS) who was admitted with spontaneous ovarian hyperstimulation syndrome (OHSS)-like extremely enlarged ovaries, which was successfully treated using gonadotropin-releasing hormone analogs and abdominal cyst aspiration in combination.

Method: This is a descriptive case report of a single patient with FPLD and PCOS.

Results: Clinical improvement was achieved 6 months after therapy besides progressive reduction in total testosterone and DHEAS. Furthermore, there was a significant improvement in hyperinsulinemia and hypertriglyceridemia. Additionally, reduction in the size of ovarian cysts, reduction in the size and number of localizations of acanthosis nigricans, reduction in scores of mFGS, and weight loss were also observed.

Conclusion: Although there are few reports in the literature describing the association between PCOS with FPLD, management of this novel spontaneous OHSS-like condition has not yet been clearly defined. In the case of extremely enlarged multicystic ovaries and severe hyperandrogenemia, GnRH analogs may be considered to prevent ovarian enlargement and reduce hyperandrogenemia, especially when other treatment options are inappropriate.

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来源期刊
CiteScore
5.90
自引率
0.00%
发文量
76
审稿时长
6-12 weeks
期刊介绍: Hormones-International Journal of Endocrinology and Metabolism is an international journal published quarterly with an international editorial board aiming at providing a forum covering all fields of endocrinology and metabolic disorders such as disruption of glucose homeostasis (diabetes mellitus), impaired homeostasis of plasma lipids (dyslipidemia), the disorder of bone metabolism (osteoporosis), disturbances of endocrine function and reproductive capacity of women and men. Hormones-International Journal of Endocrinology and Metabolism particularly encourages clinical, translational and basic science submissions in the areas of endocrine cancers, nutrition, obesity and metabolic disorders, quality of life of endocrine diseases, epidemiology of endocrine and metabolic disorders.
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