胰岛素样生长因子I (IGFI)降低血清脂蛋白(a)-对动脉粥样硬化性心血管疾病的影响

IF 1.6 4区医学 Q4 CELL BIOLOGY

Growth Hormone & Igf Research Pub Date : 2023-08-01 DOI:10.1016/j.ghir.2023.101548

Zvi Laron , Haim Werner

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引用次数: 0

摘要

肝在垂体生长激素（GH）刺激下分泌的胰岛素样生长因子I（IGFI）是儿童最重要的生长刺激激素。本综述提供的证据表明，在其额外的代谢作用中，IGF-I抑制脂蛋白（a）[Lp（a）]的合成，这是动脉粥样硬化性心血管疾病的一个独立风险因素。鉴于这种性质，建议在治疗高脂蛋白血症的药物中加入IGF-I。

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Administration of insulin like growth factor I (IGFI) lowers serum lipoprotein(a)-impact on atherosclerotic cardiovascular disease

Insulin like growth factor I (IGFI) secreted by the liver upon stimulation by pituitary growth hormone (GH) acts as the most important growth stimulating hormone in children. The present review presents evidence that among its additional metabolic effects, IGF-I suppresses the synthesis of lipoprotein(a) [Lp(a)], an independent risk factor for atherosclerotic cardiovascular disease. In view of this property, it is suggested that the addition of IGF-I to the armamentarium of hyperlipoproteinemia treatment should be considered.

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来源期刊

Growth Hormone & Igf Research 医学-内分泌学与代谢

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

57 days

期刊介绍： Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.