早期非小细胞肺癌患者的生存和生活质量:现实世界证据的文献综述

Pub Date : 2023-09-01 DOI:10.2217/lmt-2023-0003

Nick Jovanoski, Kathleen Bowes, Audrey Brown, Rossella Belleli, Danilo Di Maio, Shkun Chadda, Seye Abogunrin

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引用次数: 0

摘要

目的:评估早期NSCLC (eNSCLC)患者的长期生存和生活质量。方法:回顾观察性研究中eNSCLC患者治愈治疗后的长期生存和生活质量。结果:与I期患者相比，III期患者无病比例下降。无复发率随年龄和疾病分期而降低。晚期和血管侵犯增加晚期复发的风险。有条件的5年相对生存率不超过87%，表明enclc幸存者的死亡率更高。较低的条件生存率和相对生存率与年龄较大和疾病晚期有关。enclc幸存者的身体生活质量较差。结论:尽管有治愈意图的治疗，eNSCLC的幸存者仍然面临着显著的复发、高死亡率和生活质量下降的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Survival and quality-of-life outcomes in early-stage NSCLC patients: a literature review of real-world evidence.

Aim: Assess the long-term survival and quality-of-life outcomes in early-stage NSCLC (eNSCLC) patients.

Methods: Review of long-term survival and quality-of-life after curative treatment in eNSCLC patients in observational studies.

Results: Disease-free proportion decreased in stage III vs stage I patients. Recurrence-free proportion decreased with age and disease stage. Advanced stage and vascular invasion increased risk of late recurrence. Conditional 5-year relative survival rates did not exceed 87%, indicating higher mortality in eNSCLC survivors. Lower conditional survival rates and relative survival rates were associated with older age and advanced disease. Survivors of eNSCLC had poorer physical quality-of-life.

Conclusion: Despite curative-intent therapy, survivors of eNSCLC still face significant risks of recurrence, excess mortality, and diminished quality-of-life.

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