针对多巴胺系统上的毒蕈碱受体的作用：治疗神经精神疾病的新策略。

IF 11.2 1区医学 Q1 PHARMACOLOGY & PHARMACY

Annual review of pharmacology and toxicology Pub Date : 2024-01-23 Epub Date: 2023-08-09 DOI:10.1146/annurev-pharmtox-051921-023858

Eric J Nunes, Nii A Addy, P Jeffrey Conn, Daniel J Foster

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引用次数: 0

摘要

胆碱能对多巴胺（DA）信号传导的调节对精神分裂症、药物使用障碍和情绪相关障碍等多种疾病具有重要影响。中脑 DA 神经元的活动和末端区域的 DA 释放模式受到纹状体和后脑中胆碱能神经元的严格调控。这些胆碱能神经元可通过激活包括毒蕈碱乙酰胆碱受体（mAChR）亚型在内的多种受体来调节 DA 电路。本综述特别关注 M2、M4 和 M5 mAChR 亚型在调节 DA 神经元活动和 DA 释放中的复杂作用，以及靶向这些 mAChR 亚型的潜在临床意义。

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Targeting the Actions of Muscarinic Receptors on Dopamine Systems: New Strategies for Treating Neuropsychiatric Disorders.

Cholinergic regulation of dopamine (DA) signaling has significant implications for numerous disorders, including schizophrenia, substance use disorders, and mood-related disorders. The activity of midbrain DA neurons and DA release patterns in terminal regions are tightly regulated by cholinergic neurons found in both the striatum and the hindbrain. These cholinergic neurons can modulate DA circuitry by activating numerous receptors, including muscarinic acetylcholine receptor (mAChR) subtypes. This review specifically focuses on the complex role of M2, M4, and M5 mAChR subtypes in regulating DA neuron activity and DA release and the potential clinical implications of targeting these mAChR subtypes.

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来源期刊

Annual review of pharmacology and toxicology 医学-毒理学

CiteScore

27.80

自引率

0.00%

发文量

期刊介绍： Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.