姜黄根茎乙醇提取物对耐药菌的潜在抑菌活性研究。

Q3 Agricultural and Biological Sciences
Surachai Rattanasuk, Kitipong Wechgama, Theeraphan Chumroenphat, Orn Anong Chaiyachet, Kanlayani Charoensopharat
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引用次数: 0

摘要

背景和目标:</b>& lt; i>姜黄longa< / i>根茎是许多生物活性化合物的来源,如抗肿瘤、抗抑郁、抗菌、抗衰老和抗糖尿病。由于抗生素耐药菌的问题日益严重,有必要寻找新的抗生素来源。本研究旨在研究姜黄乙醇提取物的抑菌活性。根茎提取物抗奇异变形杆菌、鲍曼不动杆菌;耐多药肺炎克雷伯菌<(MDR-K)。材料和方法:</b>干姜黄</i>用乙醇提取根状茎。采用琼脂扩散法进行初步筛选,测定其抑菌活性。采用肉汤稀释法测定提取液的MIC和MIC。& lt; b>结果:& lt; / b>抑菌带直径最大,对奇异变形杆菌抑菌带直径为0.9 mm,对耐多药菌株抑菌带直径为0.8 mm。最低MIC值和最低MBC值分别为0.048和0.39 mg mL<sup>1</sup>抗<i>神奇变形杆菌</i>,其次是0.195和6.25 mg mL<sup>1</sup>反对MDR-K。姜黄的乙醇成分<根茎提取物对鲍曼不动杆菌无影响。& lt; b>结论:& lt; / b>本研究的新发现是姜黄的乙醇提取物;L.根茎可以消灭奇异变形杆菌</i>以及耐多药- k,可用于治疗医院内的耐抗生素细菌传染病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Potential Antibacterial Activity of Ethanolic Curcuma longa L. Rhizome Extract Against Antibiotic-Resistant Bacteria.

<b>Background and Objective:</b> <i> Curcuma longa</i> L. rhizomes are the source of many bioactive compounds such as antitumor, antidepressant, antibacterial, anti-aging and antidiabetic. Due to the growing problem of antibiotic-resistant bacteria, it is necessary to find new sources of antibiotics. This research aimed to investigate the antibacterial activity of ethanolic <i>Curcuma longa</i> L. rhizomes extract against <i>Proteus mirabilis, Acinetobacter baumannii</i> and Multidrug-Resistant <i>Klebsiella pneumoniae</i> (MDR-K). <b>Materials and Methods:</b> Dry <i>Curcuma longa</i> L. rhizomes were extracted with ethanol. The agar diffusion method was used as the primary screening of antibacterial activity determination. The broth dilution method was used to measure the MIC and MIC of the extract. <b>Results:</b> It presented the largest diameter of the inhibition zone at 0.9 mm against <i>Proteus mirabilis</i>, followed by 0.8 mm against MDR-K. The lowest MIC and MBC values were at 0.048 and 0.39 mg mL<sup>1</sup> against <i>Proteus mirabilis</i>, followed by 0.195 and 6.25 mg mL<sup>1</sup> against MDR-K. The ethanolic <i>Curcuma longa</i> L. rhizomes extract did not affect <i>Acinetobacter baumannii</i>. <b>Conclusion:</b> The new finding of this research was that the ethanolic extract from <i>Curcuma longa</i> L. rhizomes can eliminate <i>Proteus mirabilis</i> and MDR-K that can be applied to treating antibiotic-resistant bacterial infectious diseases in the hospital.

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来源期刊
Pakistan Journal of Biological Sciences
Pakistan Journal of Biological Sciences Agricultural and Biological Sciences-Agronomy and Crop Science
CiteScore
1.90
自引率
0.00%
发文量
102
期刊介绍: Pakistan Journal of Biological Sciences (PJBS) is an international, peer-reviewed and well indexed scientific journal seeks to promote and disseminate the knowledge of biological sciences by publishing outstanding research in the field. Scope of the journal includes: Cell biology, developmental biology, structural biology, microbiology, entomology, toxicology, molecular biology & genetics, biochemistry, biotechnology, biodiversity, ecology, marine biology, plant biology and bioinformatics.
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