[慢性自身免疫性甲状腺炎是多器官自身免疫综合征中的一种“信号病”]。

Q4 Medicine
E A Troshina
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引用次数: 0

摘要

世界卫生组织已宣布本世纪为“自身免疫性疾病世纪”,目前已有100多例。任何自身免疫性疾病的自然病程的特征是从潜伏和亚临床发展到临床阶段,并与特定循环自身抗体的存在有关。在患有一种已证实的自身免疫性疾病的人的一生中,很有可能连续出现其他自身免疫性病变。每四分之一的慢性自身免疫性甲状腺炎患者在其一生中发展为自身免疫性非甲状腺疾病,反之亦然,慢性自身免疫甲状腺炎存在于非甲状腺自身免疫性疾病患者中。关于自身免疫性疾病发展和进展的发病机制的现代观点使得将慢性自身免疫性甲状腺炎视为多器官自身免疫综合征的“信号病理学”成为可能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Сhronic autoimmune thyroiditis is a «signal disease» in the multiorgan autoimmune syndrome].

The current century has been declared by the WHO as the «century of autoimmune diseases», of which there are more than a hundred today. The natural course of any autoimmune disease is characterized by progression from a latent and subclinical to a clinical stage and is associated with the presence of specific circulating autoantibodies. During the life of a person with one verified autoimmune disease, there is a high probability of consecutive manifestation of other autoimmune pathologies. Every fourth patient with chronic autoimmune thyroiditis develops autoimmune non-thyroid pathologies during his life, and vice versa, chronic autoimmune thyroiditis is present among people with non-thyroid autoimmune diseases. Modern ideas about the pathogenetic mechanisms of the development and progression of autoimmune diseases make it possible to consider chronic autoimmune thyroiditis as a «signal pathology» in the multiorgan autoimmune syndrome.

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来源期刊
Problemy endokrinologii
Problemy endokrinologii Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
1.40
自引率
0.00%
发文量
59
期刊介绍: Since 1955 the “Problems of Endocrinology” (or “Problemy Endocrinologii”) Journal publishes timely articles, balancing both clinical and experimental research, case reports, reviews and lectures on pressing problems of endocrinology. The Journal is aimed to the most topical issues of endocrinology: to chemical structure, biosynthesis and metabolism of hormones, the mechanism of their action at cellular and molecular level; pathogenesis and to clinic of the endocrine diseases, new methods of their diagnostics and treatment. The Journal: features original national and foreign research articles, reflecting world endocrinology development; issues thematic editions on specific areas; publishes chronicle of major international congress sessions and workshops on endocrinology, as well as state-of-the-art guidelines; is intended for scientists, endocrinologists diabetologists and specialists of allied trade, general practitioners, family physicians and pediatrics.
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