催化二烯化反应：催化二烯化：立体选择性合成共轭二烯和多烯的新策略。

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Synthesis-Stuttgart Pub Date : 2023-06-01 Epub Date: 2022-10-25 DOI:10.1055/a-1924-2564

Jasimuddin Ahmed, Graham C Haug, Viet D Nguyen, Arka Porey, Ramon Trevino, Oleg V Larionov

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引用次数: 0

摘要

由于共轭二烯和多烯在天然产物合成、方法学和医学中发挥着核心作用，因此它们的立体选择性构建一直是一个经久不衰的合成难题。本综述重点介绍了二烯化作为直接安装共轭 π 系统不饱和四碳原子单元的新兴策略的最新进展，概述了与各种二烯化试剂的反应的区域和立体选择性、合成范围以及用于实现二烯化的催化交叉偶联过程的机理意义。

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Catalytic Dienylation: An Emergent Strategy for the Stereoselective Construction of Conjugated Dienes and Polyenes.

Stereoselective construction of conjugated dienes and polyenes has remained an enduring synthetic problem, due to the central roles they play in natural product synthesis, methodology, and medicine. This review focuses on the recent developments in dienylation as an emerging strategy for the direct installation of unsaturated four carbon atom units of conjugated π-systems, outlining the regio- and stereoselectivity, as well as the synthetic scope of reactions with various dienylating reagents and the mechanistic implications of the catalytic cross-coupling processes that are used to enable dienylation.

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来源期刊

Synthesis-Stuttgart 化学-有机化学

CiteScore

4.50

自引率

7.70%

发文量

435

审稿时长

1 months

期刊介绍： SYNTHESIS is an international full-paper journal devoted to the advancement of the science of chemical synthesis. It covers all fields of organic chemistry involving synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines. SYNTHESIS provides dependable research results with detailed and reliable experimental procedures and full characterization of all important new products as well as scientific primary data.