{"title":"电感耦合等离子串联质谱法快速测定人尿中钛","authors":"Miao Zhang, Zhifei Zhao, Liang Ding","doi":"10.19813/j.cnki.weishengyanjiu.2023.04.014","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To establish an inductively coupled plasma-tandem mass spectrometry(ICP-MS/MS) method to determinate the titanium(Ti) in human urine samples rapidly.</p><p><strong>Methods: </strong>By comparing different gas mode, ~(47)Ti was selected as the analysis element. Injecting NH_3 to the collision/reaction cell, swept by mass spectrum to determine the optimal mass spectrum conditions with the mass number of Q1=47, Q2=149(Ti ammonia hexamer). The mass spectrometry conditions of internal standard elements, integration time, reaction gas flow rate and data processing method and so on were optimized.</p><p><strong>Results: </strong>Ti had a good linear between 0.1-5.00 μg/L under the optimal analytical conditions. The detection limit was 0.1 μg/L. The RSDs of intra-day and inter-day were less than 10%, and the average recoveries were 93.7%-112.2%. The result of Seronorm Trace Elements Urine L-2 met the acceptable range.</p><p><strong>Conclusion: </strong>The method is rapid, simple, accuracy, and suitable for the rapid analysis of titanium in human urine.</p>","PeriodicalId":23789,"journal":{"name":"Wei sheng yan jiu = Journal of hygiene research","volume":"52 4","pages":"604-610"},"PeriodicalIF":0.0000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Rapid determination of titanium in human urine by inductively coupled plasma-tandem mass spectrometry].\",\"authors\":\"Miao Zhang, Zhifei Zhao, Liang Ding\",\"doi\":\"10.19813/j.cnki.weishengyanjiu.2023.04.014\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To establish an inductively coupled plasma-tandem mass spectrometry(ICP-MS/MS) method to determinate the titanium(Ti) in human urine samples rapidly.</p><p><strong>Methods: </strong>By comparing different gas mode, ~(47)Ti was selected as the analysis element. Injecting NH_3 to the collision/reaction cell, swept by mass spectrum to determine the optimal mass spectrum conditions with the mass number of Q1=47, Q2=149(Ti ammonia hexamer). The mass spectrometry conditions of internal standard elements, integration time, reaction gas flow rate and data processing method and so on were optimized.</p><p><strong>Results: </strong>Ti had a good linear between 0.1-5.00 μg/L under the optimal analytical conditions. The detection limit was 0.1 μg/L. The RSDs of intra-day and inter-day were less than 10%, and the average recoveries were 93.7%-112.2%. The result of Seronorm Trace Elements Urine L-2 met the acceptable range.</p><p><strong>Conclusion: </strong>The method is rapid, simple, accuracy, and suitable for the rapid analysis of titanium in human urine.</p>\",\"PeriodicalId\":23789,\"journal\":{\"name\":\"Wei sheng yan jiu = Journal of hygiene research\",\"volume\":\"52 4\",\"pages\":\"604-610\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Wei sheng yan jiu = Journal of hygiene research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.19813/j.cnki.weishengyanjiu.2023.04.014\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Wei sheng yan jiu = Journal of hygiene research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.19813/j.cnki.weishengyanjiu.2023.04.014","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Rapid determination of titanium in human urine by inductively coupled plasma-tandem mass spectrometry].
Objective: To establish an inductively coupled plasma-tandem mass spectrometry(ICP-MS/MS) method to determinate the titanium(Ti) in human urine samples rapidly.
Methods: By comparing different gas mode, ~(47)Ti was selected as the analysis element. Injecting NH_3 to the collision/reaction cell, swept by mass spectrum to determine the optimal mass spectrum conditions with the mass number of Q1=47, Q2=149(Ti ammonia hexamer). The mass spectrometry conditions of internal standard elements, integration time, reaction gas flow rate and data processing method and so on were optimized.
Results: Ti had a good linear between 0.1-5.00 μg/L under the optimal analytical conditions. The detection limit was 0.1 μg/L. The RSDs of intra-day and inter-day were less than 10%, and the average recoveries were 93.7%-112.2%. The result of Seronorm Trace Elements Urine L-2 met the acceptable range.
Conclusion: The method is rapid, simple, accuracy, and suitable for the rapid analysis of titanium in human urine.
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