评估在前列腺钬激光去核术中使用 5-α 还原酶抑制剂进行术前治疗的效果

R. Bultó Gonzalvo, M. Bernardello Ureta, J. Cervera Alcaide, M. Sanchez Rodriguez, M. Franco, R. Freixa Sala, J. Areal Calama, F. Agreda Castañeda
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引用次数: 0

摘要

引言和目的接受HoLEP治疗的患者通常会接受包括5-α-还原酶抑制剂(5-ARIs)在内的既往治疗。我们研究了5-ARIs预处理对HoLEP患者围手术期和术后即刻参数的影响。材料和方法使用前瞻性收集的数据库进行了一项回顾性研究,该数据库包括2017年1月至2023年1月期间在本中心接受HoLEP治疗的所有患者。对切除组织重量、去核和去骨效率(去核重量/时间和去骨重量/时间)、术后并发症、住院时间和血红蛋白下降进行了分析。结果共纳入 327 例患者,其中 173 例(52.9%)接受了 5-ARIs 治疗。为确定疗效而进行的围手术期参数调查未发现差异。在围手术期或术后并发症、住院时间或血红蛋白下降方面均未观察到差异。在我们的队列中,我们观察到使用 5-ARIs 不会影响手术效率、去核或切除。有必要进一步开展多中心研究来验证这些发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluating the effects of preoperative treatment with 5-alpha reductase inhibitors in holmium laser enucleation of the prostate

Introduction and aim

Patients treated with HoLEP are frequently treated with previous treatments, including 5-alpha-reductase inhibitors (5-ARIs). We investigated the impact of pretreatment with 5-ARIs on perioperative and immediate postoperative parameters in patients treated with HoLEP.

Material and methods

A retrospective study was performed using a prospectively collected database including all patients treated with HoLEP at our center between January 2017 and January 2023. The resected tissue weight, enucleation and morcellation efficiency (enucleation weight/time and morcellation weight/ time), postoperative complications, hospital stay and hemoglobin drop have been analyzed.

Results

A total of 327 patients were included. Of these, 173 (52.9%) were treated with 5-ARIs. No differences were found among the perioperative parameters investigated to determine efficiency. No differences were observed in peri- or postoperative complications, hospital stay or hemoglobin drop.

Conclusions

Therapy with 5-ARIs had no impact on the immediate postoperative outcomes of patients treated with HoLEP. In our cohort, we observed that the use of 5-ARIs did not affect surgical efficiency, enucleation or morcellation. Further multicenter studies will be necessary to validate these findings.

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