Melek Tufek, Pinar Nalcacioglu, Mustafa Capraz, Kenan Varol, Ahmet Turan Kaya, Nihat Aydın, Caner Kara
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Patients were divided into three groups according to BMI as group 1 with a BMI of 18.5-24.99 (<i>n</i> = 32), normal weight group; group 2 with a BMI of 30-34.99 (<i>n</i> = 35), as obese class I; and group 3 with a BMI of 35-39.99 (<i>n</i> = 35), as obese class II. The peak systolic velocity (PSV), end-diastolic velocity (EDV), resistive index, and pulsatility index values of the central retinal artery (CRA) and ophthalmic artery (OA) were evaluated with color Doppler ultrasonography. CT was measured at the subfoveal area and at 500-µm intervals nasal and temporal to the fovea up to a distance of 1500 µm by using the enhanced depth imaging technique of optical coherence tomography. Intraocular pressure (IOP) was measured with a Goldmann applanation tonometry.</p><p><strong>Results: </strong>There was a significant difference in IOP values within the groups with the highest values in group 3 (17.6 ± 2.1 mmHg) and the lowest in group 1 (12.4 ± 1.7 mmHg). The CT in groups 2 and 3 was found to be statistically significantly lower than that in group 1 at all measurement points (<i>p</i> < 0.001). There was a statistically significant negative correlation between CT at all measurement points and BMI (<i>p</i> < 0.001). The mean CRA PSV, EDV, and OA EDV values were statistically significantly lower in each obese group than those values in group 1 (<i>p</i> < 0.001). The OA PSV values were significantly lower in group 3 (36.5 ± 5.9 cm/s) than those in group 2 (43.8 ± 4 cm/s) and group 1 (44.6 ± 5.2 cm/s) (<i>p</i> < 0.001). Also, significant associations were found between BMI and CRA PSV, CRA EDV, and OA PSV values (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Obesity may predispose to eye pathologies by changing the ocular vascular circulation.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"15 ","pages":"25158414231180985"},"PeriodicalIF":2.3000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dd/4d/10.1177_25158414231180985.PMC10333989.pdf","citationCount":"2","resultStr":"{\"title\":\"The impact of obesity on ocular hemodynamics and choroidal thickness.\",\"authors\":\"Melek Tufek, Pinar Nalcacioglu, Mustafa Capraz, Kenan Varol, Ahmet Turan Kaya, Nihat Aydın, Caner Kara\",\"doi\":\"10.1177/25158414231180985\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Obesity affects microvascular structures. The effect of obesity on the ocular vascular system can be evaluated by changes in the choroidal thickness (CT) and retrobulbar blood flow (RBF).</p><p><strong>Objectives: </strong>To evaluate the CT and RBF parameters in obese patients with various body mass index (BMI) values and compare these parameters with normal weight, healthy subjects.</p><p><strong>Design: </strong>A prospective study.</p><p><strong>Methods: </strong>The study included 102 eyes of 102 female patients. Patients were divided into three groups according to BMI as group 1 with a BMI of 18.5-24.99 (<i>n</i> = 32), normal weight group; group 2 with a BMI of 30-34.99 (<i>n</i> = 35), as obese class I; and group 3 with a BMI of 35-39.99 (<i>n</i> = 35), as obese class II. The peak systolic velocity (PSV), end-diastolic velocity (EDV), resistive index, and pulsatility index values of the central retinal artery (CRA) and ophthalmic artery (OA) were evaluated with color Doppler ultrasonography. 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引用次数: 2
摘要
背景:肥胖影响微血管结构。肥胖对眼血管系统的影响可以通过脉络膜厚度(CT)和球后血流(RBF)的变化来评估。目的:评价不同体重指数(BMI)的肥胖患者的CT和RBF参数，并与体重正常的健康人进行比较。设计:前瞻性研究。方法:对102例女性患者的102只眼进行研究。根据BMI将患者分为3组:1组BMI为18.5 ~ 24.99 (n = 32)，体重正常组;2组BMI为30 ~ 34.99 (n = 35)，为肥胖I级;第三组BMI为35 ~ 39.99 (n = 35)，为肥胖II类。彩色多普勒超声检查视网膜中央动脉(CRA)和眼动脉(OA)的峰值收缩速度(PSV)、舒张末期速度(EDV)、阻力指数和脉搏指数。采用光学相干断层成像增强深度成像技术，在中央凹下区域和鼻腔、颞部至中央凹间隔500µm至1500µm处进行CT测量。眼压(IOP)用Goldmann眼压计测量。结果:两组间IOP值差异有统计学意义，3组最高(17.6±2.1 mmHg)， 1组最低(12.4±1.7 mmHg)。2、3组CT各测点均低于1组，差异有统计学意义(p p p p p p)。结论:肥胖可通过改变眼部血管循环诱发眼部病变。
The impact of obesity on ocular hemodynamics and choroidal thickness.
Background: Obesity affects microvascular structures. The effect of obesity on the ocular vascular system can be evaluated by changes in the choroidal thickness (CT) and retrobulbar blood flow (RBF).
Objectives: To evaluate the CT and RBF parameters in obese patients with various body mass index (BMI) values and compare these parameters with normal weight, healthy subjects.
Design: A prospective study.
Methods: The study included 102 eyes of 102 female patients. Patients were divided into three groups according to BMI as group 1 with a BMI of 18.5-24.99 (n = 32), normal weight group; group 2 with a BMI of 30-34.99 (n = 35), as obese class I; and group 3 with a BMI of 35-39.99 (n = 35), as obese class II. The peak systolic velocity (PSV), end-diastolic velocity (EDV), resistive index, and pulsatility index values of the central retinal artery (CRA) and ophthalmic artery (OA) were evaluated with color Doppler ultrasonography. CT was measured at the subfoveal area and at 500-µm intervals nasal and temporal to the fovea up to a distance of 1500 µm by using the enhanced depth imaging technique of optical coherence tomography. Intraocular pressure (IOP) was measured with a Goldmann applanation tonometry.
Results: There was a significant difference in IOP values within the groups with the highest values in group 3 (17.6 ± 2.1 mmHg) and the lowest in group 1 (12.4 ± 1.7 mmHg). The CT in groups 2 and 3 was found to be statistically significantly lower than that in group 1 at all measurement points (p < 0.001). There was a statistically significant negative correlation between CT at all measurement points and BMI (p < 0.001). The mean CRA PSV, EDV, and OA EDV values were statistically significantly lower in each obese group than those values in group 1 (p < 0.001). The OA PSV values were significantly lower in group 3 (36.5 ± 5.9 cm/s) than those in group 2 (43.8 ± 4 cm/s) and group 1 (44.6 ± 5.2 cm/s) (p < 0.001). Also, significant associations were found between BMI and CRA PSV, CRA EDV, and OA PSV values (p < 0.001).
Conclusion: Obesity may predispose to eye pathologies by changing the ocular vascular circulation.
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