[霍奇金淋巴瘤的诊断和分期]。

Q4 Medicine
Revue Du Praticien Pub Date : 2023-06-01
Hervé Ghesquières
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引用次数: 0

摘要

霍奇金淋巴瘤的诊断和分期。霍奇金淋巴瘤(HL)由两种不同的疾病实体组成:经典HL (cHL)和结节性淋巴细胞占优势的HL (NLPHL)。NLPHL是一种罕见的具有特定治疗管理的实体。cHL的亚群有结节性硬化、混合细胞性、淋巴细胞耗损和淋巴细胞丰富型HL。HL的初步诊断是通过活检来准确分析淋巴结的结构。大多数HL患者表现为膈上淋巴结病。初始分期由正电子发射断层扫描(PET)确定,骨髓活检现在避免了初始分期。这种分期允许定义预后组,以确定与风险相适应的初始治疗,以保持高水平的治愈率并减少长期治疗副作用。在初始治疗前,需要进行心脏超声和肺功能检查。在治疗前解决保留生育能力的问题是很重要的,对于老年患者,需要进行老年评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Diagnosis and staging of Hodgkin lymphoma].

DIAGNOSIS AND STAGING OF HODGKIN LYMPHOMA. Hodgkin lymphoma (HL) is composed of two distinct disease entities: classical HL (cHL) and nodular lymphocyte predominant HL (NLPHL). NLPHL is a rare entity with a specific therapeutic management. The subgroups of cHL are nodular sclerosis, mixed cellularity, lymphocyte depletion and lymphocyte-rich HL. The initial diagnosis of HL is made by a biopsy to analyze with accuracy the architecture of the lymph node. Most HL patients present with supradiaphragmatic lymphadenopathy. Initial staging is determined by positron emission tomography (PET) scan and bone marrow biopsy is now avoided of initial staging. This staging allows the definition of prognostic groups to determine a risk-adapted initial therapy to maintain a high level of curability and reduce long-term therapeutic side effects. Before initial treatment, cardiac ultrasound and pulmonary function tests are needed. The question of fertility preservation is important to address before treatment and for older patients the requirement of geriatric assessment.

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来源期刊
Revue Du Praticien
Revue Du Praticien Medicine-Medicine (all)
CiteScore
0.20
自引率
0.00%
发文量
161
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