{"title":"COX-2、Ki-67、Bcl-2、Bax、VEGF和CD105在口腔鳞状细胞癌组织学分级中的免疫组织化学表达","authors":"Enrico Escobar , Fernán Gómez-Valenzuela , Cristian Peñafiel , Alondra Hormazábal-Hevia , Constanza Herrera-Fuentes , Diana Mori-Aliaga","doi":"10.1016/j.patol.2023.02.005","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Oral squamous cell carcinoma (OSCC) is the most prevalent head and neck cancer. Few studies have analyzed the expression of proteins related to inflammation (COX-2) and tumor progression according to the histological grade of OSCC.</p></div><div><h3>Objective</h3><p>Analyze the immunohistochemical expression of COX-2, Ki-67 (cell proliferation), Bcl-2/Bax (apoptosis), VEGF, and CD105 (angiogenesis) according to histological grades of OSCC.</p></div><div><h3>Material and methods</h3><p>The immunohistochemical expression of COX-2, Ki-67, Bcl-2, Bax, VEGF, and CD105 of 58 cases of OSCC was analyzed. 13 cases of oral mucosa (OM) were analyzed as controls.</p></div><div><h3>Results</h3><p>COX-2, VEGF, CD105, and Ki-67 were higher in OSCC than in OM, particularly in poorly differentiated OSCC (<em>p</em> <!--><<!--> <!-->0.05). Bax expression was lower in poorly differentiated OSCC (<em>p</em> <!--><<!--> <!-->0.001). The Bcl-2/Bax ratio was higher in OSCC compared to MO (<em>p</em> <!--><<!--> <!-->0.05).</p></div><div><h3>Conclusion</h3><p>There are immunohistochemical differences according to histological grades of OSCC, which could influence clinical behavior.</p></div>","PeriodicalId":39194,"journal":{"name":"Revista Espanola de Patologia","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234467/pdf/","citationCount":"0","resultStr":"{\"title\":\"Immunohistochemical expression of COX-2, Ki-67, Bcl-2, Bax, VEGF and CD105 according to histological grading in oral squamous cell carcinoma\",\"authors\":\"Enrico Escobar , Fernán Gómez-Valenzuela , Cristian Peñafiel , Alondra Hormazábal-Hevia , Constanza Herrera-Fuentes , Diana Mori-Aliaga\",\"doi\":\"10.1016/j.patol.2023.02.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>Oral squamous cell carcinoma (OSCC) is the most prevalent head and neck cancer. Few studies have analyzed the expression of proteins related to inflammation (COX-2) and tumor progression according to the histological grade of OSCC.</p></div><div><h3>Objective</h3><p>Analyze the immunohistochemical expression of COX-2, Ki-67 (cell proliferation), Bcl-2/Bax (apoptosis), VEGF, and CD105 (angiogenesis) according to histological grades of OSCC.</p></div><div><h3>Material and methods</h3><p>The immunohistochemical expression of COX-2, Ki-67, Bcl-2, Bax, VEGF, and CD105 of 58 cases of OSCC was analyzed. 13 cases of oral mucosa (OM) were analyzed as controls.</p></div><div><h3>Results</h3><p>COX-2, VEGF, CD105, and Ki-67 were higher in OSCC than in OM, particularly in poorly differentiated OSCC (<em>p</em> <!--><<!--> <!-->0.05). Bax expression was lower in poorly differentiated OSCC (<em>p</em> <!--><<!--> <!-->0.001). The Bcl-2/Bax ratio was higher in OSCC compared to MO (<em>p</em> <!--><<!--> <!-->0.05).</p></div><div><h3>Conclusion</h3><p>There are immunohistochemical differences according to histological grades of OSCC, which could influence clinical behavior.</p></div>\",\"PeriodicalId\":39194,\"journal\":{\"name\":\"Revista Espanola de Patologia\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234467/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Espanola de Patologia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1699885523000223\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Espanola de Patologia","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1699885523000223","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Immunohistochemical expression of COX-2, Ki-67, Bcl-2, Bax, VEGF and CD105 according to histological grading in oral squamous cell carcinoma
Introduction
Oral squamous cell carcinoma (OSCC) is the most prevalent head and neck cancer. Few studies have analyzed the expression of proteins related to inflammation (COX-2) and tumor progression according to the histological grade of OSCC.
Objective
Analyze the immunohistochemical expression of COX-2, Ki-67 (cell proliferation), Bcl-2/Bax (apoptosis), VEGF, and CD105 (angiogenesis) according to histological grades of OSCC.
Material and methods
The immunohistochemical expression of COX-2, Ki-67, Bcl-2, Bax, VEGF, and CD105 of 58 cases of OSCC was analyzed. 13 cases of oral mucosa (OM) were analyzed as controls.
Results
COX-2, VEGF, CD105, and Ki-67 were higher in OSCC than in OM, particularly in poorly differentiated OSCC (p < 0.05). Bax expression was lower in poorly differentiated OSCC (p < 0.001). The Bcl-2/Bax ratio was higher in OSCC compared to MO (p < 0.05).
Conclusion
There are immunohistochemical differences according to histological grades of OSCC, which could influence clinical behavior.
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