黑人参中一种新的达玛烷类三萜皂苷的结构阐释和核磁共振谱定位

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-05-03 DOI:10.1080/10286020.2023.2253153

Xue-Ting Zhao , De-Qiang Dou , Yang Qu , Guo-Gang Zhang

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引用次数: 0

摘要

从黑参的乙醇提取物中分离出新的达玛烷型三萜皂苷，命名为22(R)-notoginsenoside Ab1 (1)，并根据一维和二维核磁共振（包括1H-NMR、13C-NMR、HSQC、HMBC、ROESY）和计算ECD阐明了它们的结构。其中，1-2 和 6-8 是首次从人参和黑参中分离出的化合物。此外，还首次用 ECD 方法区分了 22（R）- 和 22（S）- 人参皂苷 Ab1 的绝对结构。

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Structure elucidation and NMR spectral assignments of one new dammarane-type triterpenoid saponin from black ginseng

New dammarane-type triterpenoid saponin, named 22(R)-notoginsenoside Ab1 (1), together with thirteen known dammarane-type triterpenoid saponins (2-14) was isolated from the EtOH extract of black ginseng and their structures were elucidated on the basis of one- and two-dimensional NMR (including ¹H-NMR, ¹³C-NMR, HSQC, HMBC, ROESY) and calculated ECD. Among them, compounds 1-2 and 6-8 were isolated for the first time from ginseng and black ginseng. Besides, the absolute structure of 22(R)- and 22(S)- notoginsenoside Ab1 were distinguished by ECD for the first time.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.