海洋生物活性植物成分在自身免疫性疾病中的作用和机制综述。

Q2 Medicine
Dhanalekshmi Unnikrishnan Meenakshi, Gurpreet Kaur Narde, Alka Ahuja, Sammera Siddiqui
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引用次数: 0

摘要

自身免疫性疾病(Ads)的重要意义在于其慢性、高维持成本和影响许多器官和组织的复杂性。需要在患者群体中采用更全面的方法来治疗ad。获得综合治疗选择的一个革命性领域是天然植物成分。在海洋环境中可以发现大量具有良好性质的生物分子。已经从海绵、细菌、真菌、蓝藻和藻类中鉴定出许多物质,这些物质已被证明具有免疫调节活性,可能用于ad的治疗。海洋来源的生物活性物质已被证明可以影响免疫反应,在免疫治疗中是必不可少的。关于从海洋来源获得的物质用作膳食补充剂或用于治疗与免疫有关的疾病的具体影响的资料越来越多。本文讨论了许多潜在的海洋代谢化学物质的来源,如海洋动植物。许多海洋植物成分最近被分离、描述和鉴定,它们目前正在进行人类使用研究。在这篇综述中,我们试图整合有关具有抗炎和免疫调节特性的海洋植物成分的信息,并简要探讨了它们的作用方法。在当前ad发病率不断上升,缺乏更经济、安全、有效的药物来对抗可怕的人类疾病的背景下,为促进海洋植物群成分的发展提供一个基础知识,本文综述了迄今为止在这方面所做的工作。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Marine Bioactive Phytoconstituents in Autoimmune Disorders: Role and Mechanism - A Review.

The significance of Autoimmune Disorders (Ads) is underscored by their chronic nature, high maintenance costs, and complexity affecting numerous organs and tissues. A more comprehensive approach to treating Ads is required across patient populations. A revolutionary area for obtaining an integrated therapeutic option is natural phytoconstituents. Diverse biomolecules with promising properties can be found in abundance in the marine environment. Many substances have been identified from sponges, bacteria, fungi, cyanobacteria, and algae that have been shown to have immunomodulatory activities and may be used as possible treatments for Ads. Marine-derived bioactive substances have been demonstrated to affect immunological responses and to be essential in immunotherapies. The amount of information about the specific effects of substances obtained from marine sources utilized as dietary supplements or for treating immune-related diseases is growing. This paper discusses many sources of potential marine metabolic chemicals, such as maritime flora and fauna. Numerous marine phytoconstituents have recently been isolated, described, and identified, and they are currently undergoing human usage studies. We have attempted to consolidate information concerning phytoconstituents from marine sources with anti-inflammatory and immunomodulatory properties in this review, and we have briefly explored their methods of action. In order to provide a baseline of knowledge for promoting marine flora-based phytoconstituents in the current context of increasing Ads incidence, deprived of the more affordable, safe, and effective medications to combat the terrible human disease, this paper reviews the works thus far conducted on this aspect.

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来源期刊
Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry
Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
3.30
自引率
0.00%
发文量
11
期刊介绍: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new anti-inflammatory & anti-allergy agents. Publishing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.
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