利巴宁对东莨菪碱所致大鼠记忆缺损的影响。

Q3 Psychology

Central nervous system agents in medicinal chemistry Pub Date : 2023-09-01 DOI:10.2174/1871524923666230901142436

Sara Kazemi, Narges Marefati, Farimah Beheshti, Hossein Salmani, Maryam Bigham, Mahmoud Hosseini

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引用次数: 0

摘要

背景:氧化应激是阿尔茨海默病的重要诱因。本品对多种疾病均有治疗作用。探讨了奥利巴仑对东莨菪碱(Sco)所致记忆缺陷的影响。方法:4组分别为(1)对照组(2)Sco、(3-4)Sco - Olib 100、200 mg/kg。用Olib或车辆治疗两周。第三周采用Morris水迷宫(MWM)和Sco注射被动回避(PA)。最后一天，用脑和海马进行丙二醛(MDA)、过氧化氢酶(CAT)、超氧化物歧化酶(SOD)和总硫醇组的测定。结果:在5天的学习过程中，Sco增加了到达隐藏平台的时间和距离(p)结论:Olib可能通过其抗氧化特性对Sco诱导的记忆缺陷有抑制作用。

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The effect of olibanum on the rats with memory deficit induced by scopolamine.

Background: Oxidative stress is an important contributor to Alzheimer's disease. Olibanum has therapeutic effects on various diseases. The effect of Olibanum on memory deficit induced by scopolamine (Sco) was challenged.

Methods: Four groups were considered as (1) control (2) Sco, (3-4) Sco - Olib 100 and 200 mg/kg. Treatment by Olib or vehicle was done for two weeks. The third week was accompanied by the Morris water maze (MWM) and passive avoidance (PA) with Sco injection. On the last day, the brain and hippocampus were used for evaluation of the malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and a total thiol group.

Results: Sco increased the traveled time and distance to reach the hidden platform during five days of learning (p<0.01 - p<0.001) whereas it decreased the traveled time and distance (p<0.05- p<0.01) in the target area during the probe test of MWM. Sco also decreased delay time in the PA test (P<0.05 - P<0.001). Sco also decreased CAT, SOD, and thiol, whereas it, increased MDA in both the cortex and hippocampus (p<0.01 - p<0.001). Olib attenuated the impaired performance of the rats induced by Sco in MWM and PA tests. Olib reversed the increasing effects of Sco on MDA in both cortex and hippocampus and also reversed the attenuating effects of Sco on CAT, SOD, and thiol.

Conclusion: Olib had an inhibitory effect on memory deficit induced by Sco probably through its anti-oxidant property.

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来源期刊

Central nervous system agents in medicinal chemistry Psychology-Neuropsychology and Physiological Psychology

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.