坦桑尼亚多马地区大学女生使用甲硝唑紧急避孕药:一项描述性横断面研究。

Nipael M Samson, Emmanuel Izack Sumari, Valence Ndesendo, Romuald Mbwasi
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引用次数: 0

摘要

背景:甲硝唑以其抗菌和抗寄生虫的治疗作用而闻名。然而,其对生殖系统的毒性尚不清楚。在啮齿类动物中使用甲硝唑与生殖系统的毒性作用有关,包括激素改变、可育细胞数量减少和着床位置减少、胎盘盘面积大小、迷宫组成成分和海绵滋养层。它在人类中以治疗剂量使用与自然流产的风险增加有关。对人类生殖系统的影响可能导致对避孕效果的误解,因此像学生这样的性活跃个体,由于任何原因,无法获得安全的避孕服务,使用任何可能的方法来保护自己不受孕。本研究旨在调查非官方(非处方)使用甲硝唑作为一种紧急避孕药及其相关因素。方法:本研究采用分层随机抽样方法,从多多马市多多马地区的三所教育机构中抽取样本,共涉及470名参与者。收集到的数据使用SPSS版本25进行分析,进行描述性统计分析以确定频率、百分比和相关性,p结果:发现169(62.4%)使用甲硝唑作为紧急避孕药。值得注意的是,345人(73.4%)表示他们曾听说有人使用甲硝唑避孕,尤其是他们的同龄人。此外,研究年份的增加与甲硝唑作为紧急避孕药的使用减少显著相关(B = [-0.45], p =[0.02])。此外,年龄增加、在非医学院/大学学习、使用避孕方法的经历以及听说有人使用过甲硝唑与使用甲硝唑作为紧急避孕药呈正相关,尽管在统计上没有显著意义。结论:甲硝唑是一种大剂量的紧急避孕药,其使用与各种因素有关,影响其使用的原因。进一步的研究可以探索高剂量甲硝唑作为一种避孕手段的毒理学效应,并比较甲硝唑与其他紧急避孕药的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Emergency contraceptive use of Metronidazole among University female students in Dodoma region of Tanzania: a descriptive cross-sectional study.

Emergency contraceptive use of Metronidazole among University female students in Dodoma region of Tanzania: a descriptive cross-sectional study.

Background: Metronidazole is known for its therapeutic effect as antibacterial and anti-parasitic. However, its toxicity on the reproductive system remains unclear. Metronidazole use in rodents is associates with toxic effects on the reproductive system, including hormonal alterations, reduced number of fertile cells and reduced sites for implantation, size of the placental disc area, constituent elements of the labyrinth, and spongiotrophoblast layers. Its use at a therapeutic dose among humans has been associated with an increased risk of spontaneous abortion. The effects on the reproductive system in humans may result in misconceptions about contraceptive effects hence sexually active individuals like students who, for any reason, fail to access safe contraceptive services use any possible methods to protect them from conception. This study aims to investigate the unofficial (un-prescribed) use of Metronidazole as an emergency contraceptive and some of its associated factors.

Methods: This quantitative cross-sectional study involved 470 participants where stratified random sampling technique was used to obtain the sample from three educational institutions in the Dodoma Municipal, Dodoma region. Collected data were analyzed using SPSS version 25, descriptive statistical analysis was done to determine frequencies, percentages, and association, p < 0.05 was used to determine statistical significance. Further analysis using Multivariate binary logistic regression was done to determine the nature of the association between the study variables.

Results: The finding shows that 169(62.4%) use Metronidazole as an emergency contraceptive. Notably, 345(73.4%) stated that they had ever heard someone use Metronidazole for contraception, especially their peers. Furthermore, an increase in the year of study was significantly associated with reduced use of Metronidazole as an emergency contraceptive (B = [-0.45], p = [0.02]). Furthermore, an increase in age, studying in non-medical college/university, the experience of using contraceptive methods, and hearing someone ever used Metronidazole was found to be positively associated with its use as an emergency contraceptive, although not statistically significant.

Conclusion: Metronidazole was found to be used as an emergency contraceptive in high doses, different factors associated with its use, and reasons influencing its use. Further research may be done to explore the toxicological effect of high doses of Metronidazole as a contraception and compare the efficiency of Metronidazole over other emergency contraceptives.

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