胎儿早期人体脾脏及其周围脏器的三维形态分析

IF 1.3 4区 医学 Q3 PEDIATRICS
Natsuko Utsunomiya, Shiori Nakano, Motoki Katsube, Shigehito Yamada
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引用次数: 0

摘要

脾脏在其形态上有变化,被认为在妊娠第三个月获得一个明确的形状。然而,很少有研究调查脾脏在胎儿生命的前3个月的发育。本研究旨在确定妊娠第3个月脾脏的三维形态发生。本研究对30例胎儿标本(冠臀长度[CRL]: 22-103 mm)进行了磁共振成像分析。我们手工分割脾脏、胃和肾上腺,重建三维模型,并分析这些器官的体积和形状。结果表明,与其他脏器相比,脾脏大小的变化较大。根据脾表面的数量,将脾形态分为六种类型:双面、三面、四面、五面、卵形和不规则。两面脾只在小标本中可见,而三面脾和四面脾在大标本中可见。我们还发现胎儿脾表面的数量随着CRL的增大而增加。此外,3D模型显示,一些标本形成了脾脏表面,而没有与邻近器官接触。这表明脾表面可能不仅是由表面器官的压力引起的,而且是由内在程序引起的。这项研究可以更好地了解胎儿早期脾脏的正常发育,并可能有助于未来研究先天性脾脏形态异常。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Three-dimensional morphological analysis of the human spleen and its surrounding organs during the early fetal period

The spleen has variations in its morphology and is considered to acquire a defined shape in the third month of gestation. However, few studies have investigated spleen development during the first 3 months of fetal life. This study aimed to determine the three-dimensional (3D) morphogenesis of the spleen during the third month of gestation. In this study, 30 fetal specimens (crown–rump length [CRL]: 22–103 mm) were subjected to magnetic resonance imaging analysis. We manually segmented the spleen, stomach, and adrenal gland, reconstructed 3D models, and analyzed the volume and shape of these organs. The results showed that the variation in spleen size was large compared to that in other organs. Spleen morphology was classified into six types based on the number of splenic surfaces as follows: two-faced, three-faced, four-faced, five-faced, ovoid, and irregular. Two-faced spleens were only observed in small specimens, whereas three- and four-faced spleens were observed in larger specimens. We also revealed that the number of fetal splenic surfaces increased as CRL enlarged. Additionally, 3D models indicated that some specimens formed their splenic surfaces without contact with the adjacent organs. This suggested that the splenic surface may be caused not only by pressure from the faced organs but also by an intrinsic program. This study may provide a better understanding of the normal development of the spleen during the early fetal period, and may potentially assist future studies in investigating congenital morphological anomalies of the spleen.

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来源期刊
Congenital Anomalies
Congenital Anomalies PEDIATRICS-
自引率
0.00%
发文量
49
审稿时长
>12 weeks
期刊介绍: Congenital Anomalies is the official English language journal of the Japanese Teratology Society, and publishes original articles in laboratory as well as clinical research in all areas of abnormal development and related fields, from all over the world. Although contributions by members of the teratology societies affiliated with The International Federation of Teratology Societies are given priority, contributions from non-members are welcomed.
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