俄罗斯Mayak核工人肺腺癌的免疫组化分析。

IF 1.8 4区医学 Q3 ONCOLOGY

Cancer Investigation Pub Date : 2023-09-01 DOI:10.1080/07357907.2023.2218489

Gleb V Sychugov, Tamara V Azizova, Galina V Zhuntova, Evgeniya S Grigoryeva, Christopher A Loffredo, Nobuyuki Hamada, Evgeniy L Kazachkov

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引用次数: 0

摘要

采用免疫组织化学方法对暴露于α粒子和γ射线的俄罗斯核工人(n = 54)和未暴露于辐射的个体(n = 21)的肺腺癌(AdCa)标本进行了检测。估计在AdCa中Ki-67和胶原IV与α剂量呈负相关。AdCa中基质金属蛋白酶2和caspase 3组织抑制剂与γ射线剂量呈负相关，基质金属蛋白酶2和白血病抑制因子与γ射线剂量呈正相关。这些发现提供了一些证据，支持慢性辐射影响肺组织中细胞凋亡、细胞增殖和细胞外基质的改变，这些改变可能有助于放射性致癌。

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Immunohistochemical Analysis of Lung Adenocarcinoma in Russian Mayak Nuclear Workers.

Specimens of lung adenocarcinoma (AdCa) from Russian nuclear workers (n = 54) exposed to alpha particles and gamma rays and from individuals non-exposed to radiation (n = 21) were examined using immunohistochemistry. Estimated significant associations with alpha dose were negative for Ki-67 and collagen IV in AdCa. Associations with gamma-ray dose were negative for tissue inhibitor of matrix metalloproteinase 2 and caspase 3 and positive for matrix metalloproteinase 2 and leukemia inhibiting factor in AdCa. The findings provide some evidence supporting alterations in apoptosis, cell proliferation and extracellular matrix in lung tissues affected by chronic radiation exposure that can contribute to radiogenic cancerogenesis.

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来源期刊

Cancer Investigation 医学-肿瘤学

CiteScore

3.80

自引率

4.20%

发文量

审稿时长

8.5 months

期刊介绍： Cancer Investigation is one of the most highly regarded and recognized journals in the field of basic and clinical oncology. It is designed to give physicians a comprehensive resource on the current state of progress in the cancer field as well as a broad background of reliable information necessary for effective decision making. In addition to presenting original papers of fundamental significance, it also publishes reviews, essays, specialized presentations of controversies, considerations of new technologies and their applications to specific laboratory problems, discussions of public issues, miniseries on major topics, new and experimental drugs and therapies, and an innovative letters to the editor section. One of the unique features of the journal is its departmentalized editorial sections reporting on more than 30 subject categories covering the broad spectrum of specialized areas that together comprise the field of oncology. Edited by leading physicians and research scientists, these sections make Cancer Investigation the prime resource for clinicians seeking to make sense of the sometimes-overwhelming amount of information available throughout the field. In addition to its peer-reviewed clinical research, the journal also features translational studies that bridge the gap between the laboratory and the clinic.