针对前列腺特异性膜抗原的抗体J591的α-标记:来自美国某学术机构第一个专门生产实验室的技术和考虑

IF 1 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of nuclear medicine technology Pub Date : 2023-09-01 DOI:10.2967/jnmt.122.265166

Kritika Subramanian, Judith Stangl-Kremser, Lady Sawoszczyk, Vasilios Avlonitis, Andrew Gernerd, Kyla Nixon, Michael Zgaljardic, Scott Tagawa, Neil Bander, Joseph R Osborne

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引用次数: 0

摘要

前列腺特异性膜抗原的蛋白表达与前列腺癌的不利或侵袭性组织学特征相关，因此被用作诊断性PET成像放射性示踪剂和治疗靶点。在此，我们讨论了开发225Ac-DOTA-J591的方法，这是一种α-标记的靶向前列腺特异性膜抗原细胞外表位的化合物，目前正在进行早期临床试验研究。此外，我们回顾了质量控制，辐射安全措施，以及在使用这种放射免疫治疗剂之前的临床考虑。

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α-Labeling of J591, an Antibody Targeting Prostate-Specific Membrane Antigen: The Technique and Considerations from the First Dedicated Production Lab at an Academic Institution in the United States.

The protein expression of the prostate-specific membrane antigen correlates with unfavorable or aggressive histologic features of prostate cancer, resulting in use as a diagnostic PET imaging radiotracer and therapeutic target. Here, we discuss the methods to develop ²²⁵Ac-DOTA-J591, an α-labeled compound targeting an extracellular epitope of prostate-specific membrane antigen, which is currently being studied in early clinical trials. In addition, we review quality control, radiation safety measures, and clinical considerations before administration of this radioimmunotherapeutic agent.

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来源期刊

Journal of nuclear medicine technology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

1.90

自引率

15.40%

发文量