Juan Manuel Espinosa-Sanchez, Diego Kaski, Nicolas Perez-Fernandez, Angel Batuecas-Caletrio
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Most of this material is unpublished and includes over a hundred letters to or from Lorente.</p><p><strong>Results: </strong>Lorente de Nó made a substantial contribution to our understanding of the vestibular system. Amongst these, he meticulously detailed the course of the vestibular nerve and its central projections. He described the vestibulo-ocular reflex as the consequence of an integration of the various nuclei and connections across the vestibular system, rather than a simple three-neuron arc. He also highlighted the role of the reticular formation in the generation of the fast phase of the nystagmus.</p><p><strong>Conclusions: </strong>Lorente de Nó was a pioneer of modern neuro-otology, having made outstanding contributions to vestibular neuroscience, forging novel discoveries that still burn true today.</p>","PeriodicalId":49960,"journal":{"name":"Journal of Vestibular Research-Equilibrium & Orientation","volume":null,"pages":null},"PeriodicalIF":2.9000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The vestibular system: Contributions of Lorente de Nó.\",\"authors\":\"Juan Manuel Espinosa-Sanchez, Diego Kaski, Nicolas Perez-Fernandez, Angel Batuecas-Caletrio\",\"doi\":\"10.3233/VES-220034\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Rafael Lorente de Nó was a neuroscientist that worked alongside two of the giants of Medicine, the Nobel Prize winners Cajal and Bárány.</p><p><strong>Objective: </strong>To describe the contributions of Lorente de Nó to vestibular neuroscience.</p><p><strong>Methods: </strong>Detailed review of the publications of Lorente de Nó and analysis of the archives from Junta para Ampliación de Estudios e Investigaciones Científicas at Residencia de Estudiantes (Madrid, Spain), Casa de Salud Valdecilla at Hospital Universitario Marqués de Valdecilla (Santander, Spain), Becker Medical Library at Washington University (St. Louis, MO, USA), Rockefeller Archive Center (Sleepy Hollow, New York, NY, USA), Archivo Fernando de Castro (Madrid, Spain), Biblioteca Nacional de España (Madrid, Spain) and Legado Cajal at Instituto Cajal (Madrid, Spain). 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引用次数: 0
摘要
背景：Rafael Lorente de Nó是一位神经科学家，曾与两位医学巨人，诺贝尔奖得主Cajal和Bárány共事。目的：描述Lorente de Nó对前庭神经科学的贡献。方法：详细回顾Lorente de Nó的出版物，并分析Junta para AmpliacióN de Estudios e Investigaciones Científicas at Residencia de Estudiantes（西班牙马德里）、Casa de Salud Valdecilla at Hospital Universitario Marqués de Valdecilla（西班牙桑坦德）、华盛顿大学贝克尔医学图书馆（美国密苏里州圣路易斯）、，洛克菲勒档案中心（Sleepy Hollow，纽约，美国）、Archivo Fernando de Castro（西班牙马德里）、西班牙国家图书馆（西班牙马德里，西班牙）和Cajal研究所的Legado Cajal。这些材料大多未发表，其中包括100多封致洛伦特或洛伦特的信。结果：洛伦特·德诺对我们理解前庭系统做出了重大贡献。其中，他详细介绍了前庭神经及其中枢投射的过程。他将前庭-眼反射描述为前庭系统中各种细胞核和连接的整合结果，而不是简单的三神经元弧。他还强调了网状结构在眼震快速期产生中的作用。结论：Lorente de Nó是现代神经耳科的先驱，在前庭神经科学方面做出了杰出贡献，创造了至今仍在燃烧的新发现。
The vestibular system: Contributions of Lorente de Nó.
Background: Rafael Lorente de Nó was a neuroscientist that worked alongside two of the giants of Medicine, the Nobel Prize winners Cajal and Bárány.
Objective: To describe the contributions of Lorente de Nó to vestibular neuroscience.
Methods: Detailed review of the publications of Lorente de Nó and analysis of the archives from Junta para Ampliación de Estudios e Investigaciones Científicas at Residencia de Estudiantes (Madrid, Spain), Casa de Salud Valdecilla at Hospital Universitario Marqués de Valdecilla (Santander, Spain), Becker Medical Library at Washington University (St. Louis, MO, USA), Rockefeller Archive Center (Sleepy Hollow, New York, NY, USA), Archivo Fernando de Castro (Madrid, Spain), Biblioteca Nacional de España (Madrid, Spain) and Legado Cajal at Instituto Cajal (Madrid, Spain). Most of this material is unpublished and includes over a hundred letters to or from Lorente.
Results: Lorente de Nó made a substantial contribution to our understanding of the vestibular system. Amongst these, he meticulously detailed the course of the vestibular nerve and its central projections. He described the vestibulo-ocular reflex as the consequence of an integration of the various nuclei and connections across the vestibular system, rather than a simple three-neuron arc. He also highlighted the role of the reticular formation in the generation of the fast phase of the nystagmus.
Conclusions: Lorente de Nó was a pioneer of modern neuro-otology, having made outstanding contributions to vestibular neuroscience, forging novel discoveries that still burn true today.
期刊介绍：
Journal of Vestibular Research is a peer-reviewed journal that publishes experimental and observational studies, review papers, and theoretical papers based on current knowledge of the vestibular system. Subjects of the studies can include experimental animals, normal humans, and humans with vestibular or other related disorders. Study topics can include the following:
Anatomy of the vestibular system, including vestibulo-ocular, vestibulo-spinal, and vestibulo-autonomic pathways
Balance disorders
Neurochemistry and neuropharmacology of balance, both at the systems and single neuron level
Neurophysiology of balance, including the vestibular, ocular motor, autonomic, and postural control systems
Psychophysics of spatial orientation
Space and motion sickness
Vestibular rehabilitation
Vestibular-related human performance in various environments
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