花椰菜萝卜硫素治疗眼病的临床前研究

IF 6.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2023-09-01 DOI:10.1016/j.drudis.2023.103718

Faith A.A. Kwa , Bang V. Bui , Bruce R. Thompson , Lauren N. Ayton

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引用次数: 1

摘要

视力丧失在经济、情感和社会层面上给个人和社区造成重大负担。常见的病因包括年龄相关性黄斑变性(AMD)、糖尿病性视网膜病变(DR)、青光眼和视网膜色素变性(RP;也被称为“杆状锥体营养不良”)。随着全球人口的持续增长和老龄化，越来越多的人将经历视力丧失。因此，迫切需要开发能够抑制早期病理事件的治疗方法。据报道，西兰花衍生的化合物萝卜硫素(SFN)具有多种健康益处和作用方式。在这篇综述中，我们概述了SFN在眼部疾病中的临床前发现，并讨论了该化合物未来的临床试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Preclinical investigations on broccoli-derived sulforaphane for the treatment of ophthalmic disease

Vision loss causes a significant burden on individuals and communities on a financial, emotional and social level. Common causes include age-related macular degeneration (AMD), diabetic retinopathy (DR), glaucoma and retinitis pigmentosa (RP; also known as ‘rod-cone dystrophy’). As the population continues to grow and age globally, an increasing number of people will experience vision loss. Hence, there is an urgent need to develop therapies that can curb early pathological events. The broccoli-derived compound, sulforaphane (SFN), is reported to have multiple health benefits and modes of action. In this review, we outline the preclinical findings on SFN in ocular diseases and discuss the future clinical testing of this compound.

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来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.