英国生物库中英国成年人成年期间的不良事件、儿童虐待和哮喘。

IF 6.8 2区 医学 Q1 RESPIRATORY SYSTEM
Yueh-Ying Han, Wei Chen, Erick Forno, Juan C Celedón
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引用次数: 0

摘要

理由:亲密伴侣暴力(IPV)和虐待儿童分别与成人哮喘有关。没有研究同时检查成人不良事件(包括但不限于IPV)、儿童虐待和成人哮喘。目的:同时检查成人不良事件、儿童虐待和哮喘。方法:这是一项对87891名40-69岁的英国生物库参与者的成年不良事件、儿童虐待和当前哮喘的横断面研究。成人不良事件的评估采用的问题改编自全国犯罪调查。虐待儿童。使用儿童创伤筛查问卷确定。当前哮喘被定义为医生诊断的哮喘和当前喘息,并根据嗜酸性粒细胞计数进一步分类为非嗜酸性粒或嗜酸性粒(结果:在一项多变量分析中,报告≥2种成年不良事件的参与者患哮喘的几率是未报告的参与者的1.19-1.45倍,而报告≥2类虐待儿童的参与者患哮喘病的几率比未报告虐待儿童的人高1.25-1.59。按性别分层后,获得了类似的结果在女性和男性中,儿童虐待的ed,而成年后的不良事件仅与女性哮喘显著相关。在仅限于从不吸烟者和以前吸烟者的分析中也观察到了类似的发现。结论:在一组英国成年人中,虐待儿童与男性和女性目前的哮喘有关,而成年不良事件仅与女性目前的哮喘病有关。这与吸烟或嗜酸性粒细胞计数无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Adverse Events during Adulthood, Child Maltreatment, and Asthma among British Adults in the UK Biobank.

Rationale: Intimate partner violence and child maltreatment have been separately associated with asthma in adults. No study has concurrently examined of adulthood adverse events (including, but not limited to, intimate partner violence) and child maltreatment on asthma in adults. Objectives: To concurrently examine of adulthood adverse events and child maltreatment on asthma in adults. Methods: This was a cross-sectional study of adulthood adverse events and child maltreatment on current asthma in 87,891 adults 40-69 years old who participated in the UK Biobank. Adulthood adverse events were assessed using questions adapted from a national crime survey. Child maltreatment was ascertained using the Childhood Trauma Screener questionnaire. Current asthma was defined as physician-diagnosed asthma and current wheeze and was further classified as noneosinophilic or eosinophilic according to eosinophil count (<300 vs. ⩾300 cells per microliter). Results: In a multivariable analysis, participants who reported two or more types of adulthood adverse events had 1.19-1.45 times significantly higher odds of asthma than those who did not, whereas participants who reported two or more types of child maltreatment had 1.25-1.59 significantly higher odds of asthma than those who reported no child maltreatment. After stratification by sex, similar results were obtained for child maltreatment in women and men, whereas adulthood adverse events were only significantly associated with asthma in women. Similar findings were observed in analyses that were restricted to never-smokers and former smokers with <10 pack-years of smoking and in analyses of noneosinophilic and eosinophilic asthma. Conclusions: In a cohort of British adults, child maltreatment was associated with current asthma in men and women, whereas adulthood adverse events were associated with current asthma in women only. This was independent of cigarette smoking or eosinophil count.

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来源期刊
Annals of the American Thoracic Society
Annals of the American Thoracic Society Medicine-Pulmonary and Respiratory Medicine
CiteScore
9.30
自引率
3.60%
发文量
0
期刊介绍: The Annals of the American Thoracic Society (AnnalsATS) is the official international online journal of the American Thoracic Society. Formerly known as PATS, it provides comprehensive and authoritative coverage of a wide range of topics in adult and pediatric pulmonary medicine, respiratory sleep medicine, and adult medical critical care. As a leading journal in its field, AnnalsATS offers up-to-date and reliable information that is directly applicable to clinical practice. It serves as a valuable resource for clinical specialists, supporting their formative and continuing education. Additionally, the journal is committed to promoting public health by publishing research and articles that contribute to the advancement of knowledge in these fields.
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