利用灵敏的气相色谱-质谱技术测定织物中偶氮染料衍生的22种芳香胺的β-含量和γ-置信容忍区间的灵活性

IF 1.7 4区 农林科学 Q3 CHEMISTRY, ANALYTICAL
Raja Ait Lhaj, Taoufiq Saffaj, Bouchaib Ihssane
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引用次数: 0

摘要

背景:偶氮染料是纺织工业中使用最广泛的染料之一,它释放出一系列可通过皮肤吸收的致癌芳香胺。目的:利用气相色谱-质谱联用方法对织物基质中的22种偶氮染料胺进行定量分析。方法:基于总误差和β-含量、γ-置信容忍区间(β、γ-CCTI)的概念,采用“不确定度分布”的化学计量学方法,对同时测定织物中22种偶氮胺的GC-MS方法进行了全面验证。根据国际标准化组织(ISO)的ISO 17025指南,分析验证和测量不确定度估计已经发展成为确保分析结果准确性和控制与其使用相关风险的两个主要原则。结果:计算出的容差区间可用于确定各浓度水平的不确定度限。当这些限值与可接受限值相比较时,表明预期结果的很大一部分是符合的。此外,以66.7%和10%的风险比例计算的相对扩展不确定度值,在浓度水平1、15和30 mg/L时分别不超过27.7%、12.2和10.9%。结论:利用该创新方法,根据各胺的行为、要求的合格比例和可接受的容忍限度,建立了β-含量、γ-置信区间的能力和灵活性,可用于气相色谱-质谱法的质量测定。重点:建立了同时测定纺织品基质中22种偶氮胺的高效气相色谱-质谱技术。本文报道了一种新的基于不确定度概念的分析验证策略,估计了测量结果的不确定度,并研究了该方法对GC-MS方法的适用性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Flexibility of β-Content, γ-Confidence Tolerance Intervals to Qualimetry a Simultaneous 22 Aromatic Amines Derived from Azo Dyes in Fabric Using a Sensitive GC-MS Technique.

Background: Azo dyes are among the most widely used dyes in the textile industry, releasing a series of carcinogenic aromatic amines that can be absorbed through the skin.

Objective: This work aims to show that 22 azo dye amines in a textile matrix can be quantified using a GC-MS method.

Methods: Based on the notion of total error and β-content, γ-confidence tolerance intervals (β,γ-CCTI), a chemometric approach known as the "uncertainty profile" has been used to completely validate a GC-MS method for the simultaneous assay of 22 azo amines in fabrics. According to International Organization for Standardization (ISO) in ISO 17025 guidelines, analytical validation and measurement uncertainty estimates have evolved to be two main principles for ensuring the accuracy of analytical results and controlling the risk associated with their use.

Results: The calculated tolerance intervals allowed for the determination of the uncertainty limits at each concentration level. These limits when compared to the acceptable limits show that a significant portion of the expected outcomes is in conformity. Additionally, the relative expanded uncertainty values, calculated with a proportion of 66.7% and a 10% risk, do not exceed 27.7, 12.2, and 10.9% for concentration levels 1, 15, and 30 mg/L, respectively.

Conclusion: The capability and flexibility of the β-content, γ-confidence intervals have been established through the use of this innovative approach to carrying out qualimetry of the GC-MS method depending on the behavior, required conformity proportion, and acceptable tolerance limits of each amine.

Highlights: An efficient GC-MS technique for the simultaneous determination of 22 azo amines in a textile matrix has been developed. Analytical validation using a new strategy based on the uncertainty concept is reported, uncertainty associated to measurement results is estimated, and the applicability of our approach to the GC-MS method is investigated.

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来源期刊
Journal of AOAC International
Journal of AOAC International 医学-分析化学
CiteScore
3.10
自引率
12.50%
发文量
144
审稿时长
2.7 months
期刊介绍: The Journal of AOAC INTERNATIONAL publishes the latest in basic and applied research in analytical sciences related to foods, drugs, agriculture, the environment, and more. The Journal is the method researchers'' forum for exchanging information and keeping informed of new technology and techniques pertinent to regulatory agencies and regulated industries.
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