墨西哥毒蜥Astyanax mexicanus,作为细胞和发育生物学的模型系统。

IF 11.4 1区 生物学 Q1 CELL BIOLOGY
Pavani Ponnimbaduge Perera, David Perez Guerra, Misty R Riddle
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引用次数: 0

摘要

对少数模式生物的关注极大地帮助了我们对细胞和发育生物学的理解。然而,我们现在所处的时代,研究基因功能的技术可以应用于各个门,使科学家能够探索发育机制的多样性和灵活性,并对生命有更深入的了解。研究人员将无眼洞穴适应的墨西哥毒蜥Astyanax mexicanus与居住在河流中的毒蜥进行了比较,揭示了随着动物适应新环境,眼睛、色素、大脑、颅骨、血液和消化系统的发育是如何进化的。墨西哥A.mexicanus的研究突破了我们对回归和建设性性状进化的遗传和发育基础的理解。它们包括了解改变性状的突变类型,它们影响哪些细胞和发育过程,以及它们如何导致多效性。我们回顾了该领域的最新进展,并强调了未来研究的领域,包括性别分化的进化、神经嵴发育和胚胎发生的代谢调控。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Mexican Tetra, Astyanax mexicanus, as a Model System in Cell and Developmental Biology.

Our understanding of cell and developmental biology has been greatly aided by a focus on a small number of model organisms. However, we are now in an era where techniques to investigate gene function can be applied across phyla, allowing scientists to explore the diversity and flexibility of developmental mechanisms and gain a deeper understanding of life. Researchers comparing the eyeless cave-adapted Mexican tetra, Astyanax mexicanus, with its river-dwelling counterpart are revealing how the development of the eyes, pigment, brain, cranium, blood, and digestive system evolves as animals adapt to new environments. Breakthroughs in our understanding of the genetic and developmental basis of regressive and constructive trait evolution have come from A. mexicanus research. They include understanding the types of mutations that alter traits, which cellular and developmental processes they affect, and how they lead to pleiotropy. We review recent progress in the field and highlight areas for future investigations that include evolution of sex differentiation, neural crest development, and metabolic regulation of embryogenesis.

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来源期刊
CiteScore
19.50
自引率
0.00%
发文量
21
期刊介绍: The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.
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