储存在偏离指导参数的条件下时啮齿动物饮食稳定性的评估。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2023-09-01 Epub Date: 2023-08-31 DOI:10.30802/AALAS-JAALAS-22-000119
Kelly A Jimenez, Danielle R Ferguson, F Claire Hankenson
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引用次数: 0

摘要

动物资源计划的一个重要方面是为各种物种储存和提供食物。《实验动物护理和使用指南》推荐了饲料储存条件的环境参数(温度低于70°F;相对湿度低于50%),以及营养方面,如适口性、害虫控制措施、饮食质量和饲料袋的完整性。在AAALAC认证访问期间,我们收到了改善2个饲料储存地点环境条件的建议,我们假设当代牛仔饲料的包装可以承受更大的温度和湿度环境变化,而不会对完整性和适口性产生不利影响。这项研究评估了校园建筑中具有代表性的饲料储存场所,以捕捉大型和多样化动物护理项目所固有的环境条件变化。每个试验储存地点都有2袋相同的饲料(相同类型、批次和有效期),这些饲料储存于2021年6月至9月;该项目的某些方面在2022年夏天用类似的啮齿动物饲料重复进行。从时间0(对照)采集的饲料样品中分析基线营养物质,并在储存1个月和3个月后再次分析。无论试验地点和环境参数的变化如何,研究结束时在饲料中测量的总体营养值与对照值没有显著差异。视黄醇(作为维生素a的衡量标准)是唯一显著下降的成分;然而,最终的视黄醇水平始终高于小鼠适当营养所需的水平。我们向动物护理项目的利益相关者简要介绍了这项研究的结果,目的是在未来的AAALAC现场考察中验证我们的储存条件是否足以维持包装啮齿动物饲料的营养质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of Rodent Diet Stability when Stored in Conditions that Diverge from Guide Parameters.

An essential aspect of animal resource programs is the storage and provision of food for a variety of species. Environmental parameters for feed storage conditions (temperature less than 70 °F; relative humidity less than 50%) are recommended in the Guide for the Care and Use of Laboratory Animals, along with aspects of nutrition such as palatability, vermin-control measures, diet quality, and integrity of feed bags. After receiving a suggestion for improvement for environmental conditions in 2 feed storage locations during an AAALAC accreditation visit, we hypothesized that the packaging of contemporary rodent feed could sustain wider environmental variations in temperature and humidity without adverse impact on integrity and palatability. This study evaluated representative feed storage sites across campus buildings to capture the variation in environmental conditions that are inherent to large and diverse animal care programs. Each test storage location held 2 identical bags of feed (same type, lot, and expiration date) that were stored from June to September of 2021; some aspects of the project were repeated during summer 2022 with a similar rodent feed. Baseline nutrients were analyzed from feed samples collected at time 0 (control) and again after 1 and 3mo of storage. The overall nutritional values measured in feed at the end of the study were not significantly different from control values, regardless of test site and variation in environmental parameters. Retinol (as a measure of Vitamin A) was the only component that decreased significantly; however, final retinol levels were consistently above those necessary for appropriate nutrition for mice. Our animal care program stakeholders were briefed on the outcomes of this study with the intent to verify at future AAALAC site visits that our storage conditions are adequate for maintaining the nutritional quality of packaged rodent feed.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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