确定并满足原发性皮肤 B 细胞淋巴瘤未满足的临床需求:一个特设国际小组的共识文件。

IF 3.3 4区 医学 Q2 HEMATOLOGY
Pietro Quaglino, Nicola Pimpinelli, Pier Luigi Zinzani, Marco Paulli, Stefano Pileri, Emilio Berti, Lorenzo Cerroni, Joan Guitart, Youn H. Kim, Serena Rupoli, Marco Santucci, Gabriele Simontacchi, Maarten Vermeer, Richard Hoppe, Barbara Pro, Steven H. Swerdlow, Giovanni Barosi
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引用次数: 0

摘要

原发性皮肤B细胞淋巴瘤(PCBCL)是一种淋巴细胞增生性疾病,诊断时出现在皮肤上,没有皮肤外表现的证据。由于很少有大规模研究和对照临床试验,因此缺乏以证据为基础的临床治疗指南。在此,由 16 位从事 PCBCL 研究和临床实践的专家组成的专家小组介绍并讨论了 PCBCL 临床治疗中一系列尚未满足的主要临床需求 (UCN)。专家小组就有关已确定临床需求的临床决策的适当性提出了建议,并提议开展研究以增进解决这些需求所需的知识。建议和提案是在对科学文献进行全面分析后,通过多步骤的正式程序达成共识的。建议和提案涉及 PCBCL 分类的不确定性、诊断的优化、预后的优化、分期的优化以及治疗策略的关键问题,尤其侧重于新疗法。这些建议不仅供专家使用,更重要的是供在 PCBCL 领域经验有限的皮肤科和血液科医生以及全科医生使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Identifying and addressing unmet clinical needs in primary cutaneous B-cell lymphoma: A consensus-based paper from an ad-hoc international panel

Primary cutaneous B-cell lymphomas (PCBCLs) are lymphoproliferative disorders that appear on the skin without evidence of extracutaneous manifestations at the time of diagnosis. There is a lack of evidence-based guidelines for their clinical management due to the availability of very few large scale studies and controlled clinical trials. Here we present and discuss a series of major unmet clinical needs (UCNs) in the management of PCBCLs by a panel of 16 experts involved in research and clinical practice of PCBCL. The Panel produced recommendations on the appropriateness of the clinical decisions concerning the identified clinical needs and proposed research for improving the knowledge needed to solve them. Recommendations and proposals were achieved by multiple-step formalized procedures to reach a consensus after a comprehensive analysis of the scientific literature. Recommendations and proposals lay in the domain of classification uncertainties of PCBCL, optimization of diagnosis, optimization of prognosis, optimization of staging and critical issues on therapeutic strategies with particular focus on new treatments. These recommendations are intended for use not only by experts but above all by dermatologists and hematologists with limited experience in the field of PCBCLs as well as general practitioners.

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来源期刊
Hematological Oncology
Hematological Oncology 医学-血液学
CiteScore
4.20
自引率
6.10%
发文量
147
审稿时长
>12 weeks
期刊介绍: Hematological Oncology considers for publication articles dealing with experimental and clinical aspects of neoplastic diseases of the hemopoietic and lymphoid systems and relevant related matters. Translational studies applying basic science to clinical issues are particularly welcomed. Manuscripts dealing with the following areas are encouraged: -Clinical practice and management of hematological neoplasia, including: acute and chronic leukemias, malignant lymphomas, myeloproliferative disorders -Diagnostic investigations, including imaging and laboratory assays -Epidemiology, pathology and pathobiology of hematological neoplasia of hematological diseases -Therapeutic issues including Phase 1, 2 or 3 trials as well as allogeneic and autologous stem cell transplantation studies -Aspects of the cell biology, molecular biology, molecular genetics and cytogenetics of normal or diseased hematopoeisis and lymphopoiesis, including stem cells and cytokines and other regulatory systems. Concise, topical review material is welcomed, especially if it makes new concepts and ideas accessible to a wider community. Proposals for review material may be discussed with the Editor-in-Chief. Collections of case material and case reports will be considered only if they have broader scientific or clinical relevance.
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