黑色素瘤中的多发性脑膜病：病理生理学和临床护理的最新进展。

IF 3.9 3区医学 Q2 CELL BIOLOGY

Pigment Cell & Melanoma Research Pub Date : 2023-08-25 DOI:10.1111/pcmr.13116

Inna Smalley, Adrienne Boire, Priscilla Brastianos, Harriet M. Kluger, Eva Hernando-Monge, Peter A. Forsyth, Kamran A. Ahmed, Keiran S. M. Smalley, Sherise Ferguson, Michael A. Davies, Isabella C. Glitza Oliva

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引用次数: 0

摘要

转移性黑色素瘤（LMD）仍然是临床治疗中的一大难题。患者的治疗效果仍然不佳，几乎所有的临床试验都将 LMD 患者排除在外。不过，最近的试验证明了对这些患者进行前瞻性临床试验的可行性。此外，对 LMD 病理生理学的新认识正在确定合理的新治疗策略。在此，我们将介绍对转移性黑色素瘤 LMD 的认识和治疗方案的最新进展。我们还指出了未来重点关注的关键领域，以加快这一具有挑战性的新兴领域的进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Leptomeningeal disease in melanoma: An update on the developments in pathophysiology and clinical care

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Leptomeningeal disease in melanoma: An update on the developments in pathophysiology and clinical care

Leptomeningeal disease (LMD) remains a major challenge in the clinical management of metastatic melanoma patients. Outcomes for patient remain poor, and patients with LMD continue to be excluded from almost all clinical trials. However, recent trials have demonstrated the feasibility of conducting prospective clinical trials in these patients. Further, new insights into the pathophysiology of LMD are identifying rational new therapeutic strategies. Here we present recent advances in the understanding of, and treatment options for, LMD from metastatic melanoma. We also annotate key areas of future focus to accelerate progress for this challenging but emerging field.

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来源期刊

Pigment Cell & Melanoma Research 医学-皮肤病学

CiteScore

8.90

自引率

2.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Pigment Cell & Melanoma Researchpublishes manuscripts on all aspects of pigment cells including development, cell and molecular biology, genetics, diseases of pigment cells including melanoma. Papers that provide insights into the causes and progression of melanoma including the process of metastasis and invasion, proliferation, senescence, apoptosis or gene regulation are especially welcome, as are papers that use the melanocyte system to answer questions of general biological relevance. Papers that are purely descriptive or make only minor advances to our knowledge of pigment cells or melanoma in particular are not suitable for this journal. Keywords Pigment Cell & Melanoma Research, cell biology, melatonin, biochemistry, chemistry, comparative biology, dermatology, developmental biology, genetics, hormones, intracellular signalling, melanoma, molecular biology, ocular and extracutaneous melanin, pharmacology, photobiology, physics, pigmentary disorders