2型糖尿病持续时间与癌症发病率:英国的一项观察性研究。

IF 14.8 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Diabetes Care Pub Date : 2023-11-01 DOI:10.2337/dc23-1013
Francesco Zaccardi, Suping Ling, Karen Brown, Melanie Davies, Kamlesh Khunti
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引用次数: 0

摘要

目的:探讨2型糖尿病持续时间与癌症发病率的关系。研究设计和方法:在临床实践研究数据链接数据库中,我们确定了130764名诊断时年龄≥35岁的2型糖尿病患者,他们与医院和死亡率记录相关。我们使用具有两个时间尺度的性标准Royston-Parmar模型,根据年龄和糖尿病持续时间,估计1998年1月1日至2019年1月14日期间英国所有癌症、四种最常见的癌症(结直肠癌、肺癌、前列腺癌、乳腺癌)和肥胖相关癌症(如肝癌、卵巢癌)的发病率。结果:在1089923人年中,发生了18977起癌症事件。在同一年龄段,从诊断到20年,男性和女性的所有癌症发病率没有变化;相反,在任何时期内,年龄与癌症发病率之间都存在着强烈的正相关。在男性中,20年与5年的患病率(95%CI)在60岁时为1.18(0.82-1.69),在80岁时为0.90(0.75-1.08);女性的相应比例分别为1.07(0.71-1.63)和0.84(0.66-1.05)。这一模式也适用于四种最常见的癌症。对于肥胖相关癌症,尽管BMI较高的个体的发病率通常较高,但在任何BMI水平下,与持续时间都没有关联。结论:在这项研究中,我们没有发现2型糖尿病持续时间与癌症风险之间存在关联的证据,观察到持续时间越长,风险越高,与衰老有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Duration of Type 2 Diabetes and Incidence of Cancer: An Observational Study in England.

Objective: To investigate the association between duration of type 2 diabetes and cancer incidence.

Research design and methods: In the Clinical Practice Research Datalink database, we identified 130,764 individuals with type 2 diabetes aged ≥35 years at diagnosis who were linked to hospital and mortality records. We used sex-stratified Royston-Parmar models with two timescales to estimate incidence rates of all cancers, the four commonest cancers in the U.K. (colorectal, lung, prostate, breast), and the obesity-related cancers (e.g., liver, ovary) between 1 January 1998 and 14 January 2019, by age and diabetes duration.

Results: During 1,089,923 person-years, 18,977 incident cancers occurred. At the same age, rates of all cancers in men and women did not vary across durations ranging from diagnosis to 20 years; conversely, for any duration, there was a strong, positive association between age and cancer rates. In men, the rate ratio (95% CI) comparing 20 with 5 years of duration was 1.18 (0.82-1.69) at 60 years of age and 0.90 (0.75-1.08) at 80 years; corresponding ratios in women were 1.07 (0.71-1.63) and 0.84 (0.66-1.05). This pattern was observed also for the four commonest cancers. For obesity-related cancers, although rates were generally higher in individuals with a higher BMI, there was no association with duration at any level of BMI.

Conclusions: In this study, we did not find evidence of an association between duration of type 2 diabetes and risk of cancer, with the higher risk observed for longer durations related to ageing.

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来源期刊
Diabetes Care
Diabetes Care 医学-内分泌学与代谢
CiteScore
27.80
自引率
4.90%
发文量
449
审稿时长
1 months
期刊介绍: The journal's overarching mission can be captured by the simple word "Care," reflecting its commitment to enhancing patient well-being. Diabetes Care aims to support better patient care by addressing the comprehensive needs of healthcare professionals dedicated to managing diabetes. Diabetes Care serves as a valuable resource for healthcare practitioners, aiming to advance knowledge, foster research, and improve diabetes management. The journal publishes original research across various categories, including Clinical Care, Education, Nutrition, Psychosocial Research, Epidemiology, Health Services Research, Emerging Treatments and Technologies, Pathophysiology, Complications, and Cardiovascular and Metabolic Risk. Additionally, Diabetes Care features ADA statements, consensus reports, review articles, letters to the editor, and health/medical news, appealing to a diverse audience of physicians, researchers, psychologists, educators, and other healthcare professionals.
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