透明质酸基质在隆鼻术中的应用。

IF 1.6 4区 生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Biotechnic & Histochemistry Pub Date : 2023-11-01 Epub Date: 2023-08-30 DOI:10.1080/10520295.2023.2248889
Zuleyha Erisgin, Omer Hizli, Guven Yildirim, Cengiz Sivrikaya, Ahmet Burcin Sarisoy, Yonca Avci, Kursat Murat Ozcan
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引用次数: 0

摘要

隆鼻术失败或面部外伤导致鞍鼻畸形的患者有时需要隆鼻;找到合适的接枝材料仍然是这个过程的一个重要问题。我们研究了透明质酸基质作为同种异体移植物在兔隆鼻模型中的应用。我们对八只兔子的鼻骨进行了截骨。四只动物作为对照组进行假手术,四只动物给予盐水凝胶透明质酸基质和切片软骨的混合物。实验结束时进行超声检查和三维重建断层扫描。处死动物后,检查鼻腔组织的组织病理学,并比较两组之间的胶原评分和毛细血管数量。与对照组相比,透明质酸基质组的胶原和毛细血管明显增加。透明质酸基质组的中位胶原评分显著高于对照组。尽管透明质酸基质组的毛细血管数量大于对照组,但差异无统计学意义。在临床实践中,三周对于骨折末端的粘连是足够的;然而,我们在这两组中都没有发现骨化。透明质酸基质可能是隆鼻术的一种有用的替代补充剂。胶原的发育与膜骨化相当;然而,评估完全骨化需要更长的实验时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Use of hyaluronic acid matrix in dorsal augmentation rhinoplasty.

Augmentation rhinoplasty sometimes is required for patients with saddle nose deformity caused by failed rhinoplasty or facial trauma; finding appropriate grafting material remains a significant problem for this procedure. We investigated hyaluronic acid matrix as an allograft for dorsal augmentation rhinoplasty in a rabbit model. We performed an osteotomy on the nasal bones of eight rabbits. Four animals were sham operated as the control group and four were administered a mixture of saline-gelled hyaluronic acid matrix and sliced cartilage. Ultrasonography and three-dimensional reconstruction tomography were performed at the end of the experimental period. After sacrifice of the animals, nasal tissues were examined for histopathology, and both collagen scores and number of capillaries were compared between the two groups. Increased collagen and capillaries were apparent in the hyaluronic acid matrix group compared to controls. The median collagen score was significantly greater for the hyaluronic acid matrix group than for the control group. Although the number of capillaries for the hyaluronic acid matrix group was greater than for the control group, the difference was not statistically significant. Three weeks is sufficient for adhesion of ends of fractures in clinical practice; however, we found no ossification at this time in either group. A hyaluronic acid matrix may be a useful alternative supplement for dorsal augmentation rhinoplasty. Development of collagen was commensurate with membranous ossification; however, assessment of complete ossification requires a longer experimental period.

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来源期刊
Biotechnic & Histochemistry
Biotechnic & Histochemistry 生物-生物工程与应用微生物
CiteScore
3.40
自引率
6.20%
发文量
46
审稿时长
6-12 weeks
期刊介绍: Biotechnic & Histochemistry (formerly Stain technology) is the official publication of the Biological Stain Commission. The journal has been in continuous publication since 1926. Biotechnic & Histochemistry is an interdisciplinary journal that embraces all aspects of techniques for visualizing biological processes and entities in cells, tissues and organisms; papers that describe experimental work that employs such investigative methods are appropriate for publication as well. Papers concerning topics as diverse as applications of histochemistry, immunohistochemistry, in situ hybridization, cytochemical probes, autoradiography, light and electron microscopy, tissue culture, in vivo and in vitro studies, image analysis, cytogenetics, automation or computerization of investigative procedures and other investigative approaches are appropriate for publication regardless of their length. Letters to the Editor and review articles concerning topics of special and current interest also are welcome.
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