性交后疑似丁丙诺啡沉淀阿片类药物戒断一例报告。

IF 0.9 Q3 ANESTHESIOLOGY

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2023-12-01 Epub Date: 2023-08-28 DOI:10.1080/15360288.2023.2250344

Davene Lynch, Lyndsey Chitty, Brittany Johnson, Amie L Hoefnagel

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引用次数: 1

摘要

丁丙诺啡是一种部分阿片受体激动剂，是治疗阿片使用障碍(OUD)的常用处方药。有证据表明，基于脂溶性和电离程度，药物可能通过离子捕获过程进入男性泌尿生殖道(1)。虽然对药物在精液中的药代动力学知之甚少，但pH被认为起着不可或缺的作用。关于宫颈通过精液吸收药物的证据有限。这也促使调查这一事件的频率及其对该人群治疗的影响。

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Suspected Buprenorphine-Precipitated Opioid Withdrawal following Intercourse: A Case Report.

Buprenorphine, a partial mu-opioid receptor agonist, is a commonly prescribed medication for opioid use disorder (OUD). There is evidence that drugs may enter the male genitourinary tract by an ion-trapping process, based on the lipid solubility and degree of ionization (1). While little is known about the pharmacokinetics of drugs in seminal fluid, pH is thought to play an integral role. Limited evidence exists surrounding cervical absorption of drugs via seminal fluid transmission. This also prompts survey of the frequency of this event and the influence on treatment within this population.

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来源期刊

Journal of Pain & Palliative Care Pharmacotherapy ANESTHESIOLOGY-

CiteScore

1.60

自引率

9.10%

发文量