针对转移性黑色素瘤的肿瘤溶解性鞘内疗法。

IF 4.2 3区 医学 Q2 ONCOLOGY
Clinical & Experimental Metastasis Pub Date : 2024-08-01 Epub Date: 2023-08-09 DOI:10.1007/s10585-023-10228-4
Danielle K DePalo, Matthew C Perez, Anne Huibers, Roger Olofsson Bagge, Jonathan S Zager
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引用次数: 0

摘要

大约每 10 名黑色素瘤患者中就有 1 名会出现转移瘤(ITM),而且病程变化很大。手术切除是治疗的黄金标准;但是,由于转移瘤的大小、分布和/或解剖学受累,通常无法通过手术切除。溶瘤病毒疗法是治疗 ITM 的一类非手术疗法。它们通过天然或基因修饰因子对肿瘤细胞的选择性感染,诱导肿瘤细胞溶解和全身抗肿瘤活性。虽然有许多溶瘤病毒疗法正处于治疗 ITM 的不同开发阶段,但本文将重点讨论两种最成熟的基于疱疹病毒的疗法的机制和现有文献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oncolytic intralesional therapy for metastatic melanoma.

In-transit metastasis (ITM) develop in approximately 1 in 10 patients with melanoma and the disease course can vary widely. Surgical resection is the gold-standard treatment; however, ITM are often surgically unresectable due to size, distribution, and/or anatomic involvement. Oncolytic viral therapies are one category of non-surgical treatment options available for ITM. They induce tumor cell lysis and systemic anti-tumor activity through selective infection of tumor cells by naturally occurring or genetically modified factors. While there are numerous oncolytic viral therapies in various stages of development for the treatment of ITM, this discussion focuses on the mechanism and available literature for the two most established herpes virus-based therapies.

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来源期刊
CiteScore
7.80
自引率
5.00%
发文量
55
审稿时长
12 months
期刊介绍: The Journal''s scope encompasses all aspects of metastasis research, whether laboratory-based, experimental or clinical and therapeutic. It covers such areas as molecular biology, pharmacology, tumor biology, and clinical cancer treatment (with all its subdivisions of surgery, chemotherapy and radio-therapy as well as pathology and epidemiology) insofar as these disciplines are concerned with the Journal''s core subject of metastasis formation, prevention and treatment.
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