骨肉瘤的六大途径靶向治疗。

IF 2.9 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Shuxing Wang, Quanlei Ren, Guoqing Li, Xiaoxuan Zhao, Xing Zhao, Zhen Zhang
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引用次数: 0

摘要

骨肉瘤是最常见的原发性骨恶性肿瘤,具有高度的局部侵袭倾向。虽然近年来有大量的研究集中在化疗和联合化疗方案上,但对于复发或转移性OS的治疗还没有特别完善的方案,预后仍然相对较差。靶向治疗作为一种新的治疗方法,为骨肉瘤患者提供了一种新的治疗方案,具有广阔的应用前景。本文综述了骨肉瘤靶向治疗的最新进展,并通过六大途径对骨肉瘤相应靶点的研究进行了总结。这些研究可以为骨肉瘤患者需要的新疗法铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Targeted Therapies for Osteosarcoma via Six Major Pathways.

Osteosarcoma is the most common primary bone malignancy and has a high tendency of local invasion. Although a lot of studies have focused on chemotherapy and combination chemotherapy regimens in recent years, still, there is no particularly perfect regimen for the treatment of relapsed or metastatic OS, and the prognosis is still relatively poor. As a new therapeutic method, targeted therapy provides a new scheme for patients with osteosarcoma and has a wide application prospect. This article reviews the latest progress of targeted therapy for osteosarcoma, and summarizes the research on the corresponding targets of osteosarcoma through six major pathways. These studies can pave the way for new treatments for osteosarcoma patients who need them.

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来源期刊
Current molecular pharmacology
Current molecular pharmacology Pharmacology, Toxicology and Pharmaceutics-Drug Discovery
CiteScore
4.90
自引率
3.70%
发文量
112
期刊介绍: Current Molecular Pharmacology aims to publish the latest developments in cellular and molecular pharmacology with a major emphasis on the mechanism of action of novel drugs under development, innovative pharmacological technologies, cell signaling, transduction pathway analysis, genomics, proteomics, and metabonomics applications to drug action. An additional focus will be the way in which normal biological function is illuminated by knowledge of the action of drugs at the cellular and molecular level. The journal publishes full-length/mini reviews, original research articles and thematic issues on molecular pharmacology. Current Molecular Pharmacology is an essential journal for every scientist who is involved in drug design and discovery, target identification, target validation, preclinical and clinical development of drugs therapeutically useful in human disease.
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