炎症性低铁血症:宿主对感染的先天防御

IF 2.1 4区医学 Q3 HEMATOLOGY

Blood Cells Molecules and Diseases Pub Date : 2023-06-21 DOI:10.1016/j.bcmd.2023.102777

Tomas Ganz , Elizabeta Nemeth

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引用次数: 2

摘要

铁是微生物、植物和动物必需的营养物质。多细胞生物已经进化出多种策略，通过限制微生物获得铁来控制入侵微生物。炎症的低铁血症是一种快速作用的机体反应，它可以阻止微生物容易接近的铁物质的形成。本文从进化的角度探讨炎症性低铁血症的机制、宿主防御功能及其临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Hypoferremia of inflammation: Innate host defense against infections

Iron is an essential nutrient for microbes, plants and animals. Multicellular organisms have evolved multiple strategies to control invading microbes by restricting microbial access to iron. Hypoferremia of inflammation is a rapidly-acting organismal response that prevents the formation of iron species that would be readily accessible to microbes. This review takes an evolutionary perspective to explore the mechanisms and host defense function of hypoferremia of inflammation and its clinical implications.

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来源期刊

Blood Cells Molecules and Diseases 医学-血液学

CiteScore

4.90

自引率

0.00%

发文量

审稿时长

14 days

期刊介绍： Blood Cells, Molecules & Diseases emphasizes not only blood cells, but also covers the molecular basis of hematologic disease and studies of the diseases themselves. This is an invaluable resource to all those interested in the study of hematology, cell biology, immunology, and human genetics.