Trogocytosis挑战谱系标记和单克隆抗体的细胞特异性。

IF 67.7 1区医学 Q1 IMMUNOLOGY

Nature Reviews Immunology Pub Date : 2023-07-25 DOI:10.1038/s41577-023-00920-7

Jasmin Ochs, Silke Häusser-Kinzel, Martin S. Weber

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引用次数: 0

摘要

细胞间表面分子的转移是对细胞类型独特表面标志物概念的挑战，并表明用于治疗目的的单克隆抗体的特异性可能不如以前想象的那么强。此外，逆行细胞吞噬可能会将功能特性转移到新的细胞类型中。这一过程可用于实验追踪与疾病相关的细胞-细胞相互作用。这篇评论文章提出，通过逆行细胞吞噬作用在相互作用的细胞之间转移表面分子可能会影响单克隆抗体的细胞特异性以及接收细胞的功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Trogocytosis challenges the cellular specificity of lineage markers and monoclonal antibodies

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Trogocytosis challenges the cellular specificity of lineage markers and monoclonal antibodies

The transfer of surface molecules between cells by trogocytosis challenges the concept of cell type-unique surface markers and indicates that monoclonal antibodies used for therapeutic purposes may be less specific than previously thought. Furthermore, trogocytosis may transfer functional properties to new cell types. This process could be used experimentally to trace disease-relevant cell–cell interactions. This Comment article proposes that the transfer of surface molecules between interacting cells by trogocytosis might affect the cellular specificity of monoclonal antibodies, as well as the functionality of receiving cells.

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来源期刊

Nature Reviews Immunology 医学-免疫学

CiteScore

93.40

自引率

0.40%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.