晚期胃癌DCE-MRI放射组学特征与CD8+和CD4+ TILs的关系

IF 2.3 4区 医学 Q3 ONCOLOGY
Huizhen Huang, Zhiheng Li, Yue Xia, Zhenhua Zhao, Dandan Wang, Hongyan Jin, Fang Liu, Ye Yang, Liyijing Shen, Zengxin Lu
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引用次数: 0

摘要

目的:探讨进展期胃癌患者肿瘤浸润性CD8+和CD4+ T细胞水平与动态磁共振成像(DCE-MRI)定量药动学参数的相关性。方法:回顾性分析103例经组织病理学证实的晚期胃癌(AGC)患者的资料。通过Omni Kinetics软件获得Kep、Ktrans和Ve三个药代动力学参数及其放射组学特征。免疫组织化学染色检测CD4+和CD8+ TILs。随后进行统计分析以评估放射组学特征与CD4+和CD8+ TIL密度之间的相关性。结果:本研究纳入的所有患者最终分为CD8+ TILs低密度组(n = 51) (CD8+ TILs < 138)或高密度组(n = 52) (CD8+ TILs≥138)和CD4+ TILs低密度组(n = 51) (CD4+ TILs < 87)或高密度组(n = 52) (CD4+ TILs≥87)。基于Kep和Ktrans的Skewness与CD8+ TIL水平均呈中度负相关(r = 0.630-0.349, p < 0.001),其中基于Kep的ClusterShade与CD8+ TIL水平负相关最高(r = -0.630, p < 0.001)。基于惯性的Kep与CD4+ TIL水平呈中度正相关(r = 0.549, p < 0.001),基于惯性的Kep与CD4+ TIL水平呈中度负相关(r = -0.616, p < 0.001),相关系数最高。采用ROC曲线评价上述特征的诊断效果。对于CD8+ TILs, Kep的ClusterShade的平均曲线下面积(AUC)最高(0.863)。对于CD4+ til, Kep的相关性最高,平均AUC为0.856。结论:DCE-MRI的放射组学特征与AGC中肿瘤浸润性CD8+和CD4+ T细胞的表达相关,具有无创性评估AGC患者CD8+和CD4+ TILs表达的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Association between radiomics features of DCE-MRI and CD8<sup>+</sup> and CD4<sup>+</sup> TILs in advanced gastric cancer.

Association between radiomics features of DCE-MRI and CD8<sup>+</sup> and CD4<sup>+</sup> TILs in advanced gastric cancer.

Association between radiomics features of DCE-MRI and CD8<sup>+</sup> and CD4<sup>+</sup> TILs in advanced gastric cancer.

Association between radiomics features of DCE-MRI and CD8+ and CD4+ TILs in advanced gastric cancer.

Objective: The aim of this investigation was to explore the correlation between the levels of tumor-infiltrating CD8+ and CD4+ T cells and the quantitative pharmacokinetic parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with advanced gastric cancer. Methods: We retrospectively analyzed the data of 103 patients with histopathologically confirmed advanced gastric cancer (AGC). Three pharmacokinetic parameters, Kep, Ktrans, and Ve, and their radiomics characteristics were obtained by Omni Kinetics software. Immunohistochemical staining was used to determine CD4+ and CD8+ TILs. Statistical analysis was subsequently performed to assess the correlation between radiomics characteristics and CD4+ and CD8+ TIL density. Results: All patients included in this study were finally divided into either a CD8+ TILs low-density group (n = 51) (CD8+ TILs < 138) or a high-density group (n = 52) (CD8+ TILs ≥ 138), and a CD4+ TILs low-density group (n = 51) (CD4+ TILs < 87) or a high-density group (n = 52) (CD4+ TILs ≥ 87). ClusterShade and Skewness based on Kep and Skewness based on Ktrans both showed moderate negative correlation with CD8+ TIL levels (r = 0.630-0.349, p < 0.001), with ClusterShade based on Kep having the highest negative correlation (r = -0.630, p < 0.001). Inertia-based Kep showed a moderate positive correlation with the CD4+ TIL level (r = 0.549, p < 0.001), and the Correlation based on Kep showed a moderate negative correlation with the CD4+ TIL level, which also had the highest correlation coefficient (r = -0.616, p < 0.001). The diagnostic efficacy of the above features was assessed by ROC curves. For CD8+ TILs, ClusterShade of Kep had the highest mean area under the curve (AUC) (0.863). For CD4+ TILs, the Correlation of Kep had the highest mean AUC (0.856). Conclusion: The radiomics features of DCE-MRI are associated with the expression of tumor-infiltrating CD8+ and CD4+ T cells in AGC, which have the potential to noninvasively evaluate the expression of CD8+ and CD4+ TILs in AGC patients.

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来源期刊
CiteScore
6.30
自引率
0.00%
发文量
134
审稿时长
4-8 weeks
期刊介绍: Pathology & Oncology Research (POR) is an interdisciplinary Journal at the interface of pathology and oncology including the preclinical and translational research, diagnostics and therapy. Furthermore, POR is an international forum for the rapid communication of reviews, original research, critical and topical reports with excellence and novelty. Published quarterly, POR is dedicated to keeping scientists informed of developments on the selected biomedical fields bridging the gap between basic research and clinical medicine. It is a special aim for POR to promote pathological and oncological publishing activity of colleagues in the Central and East European region. The journal will be of interest to pathologists, and a broad range of experimental and clinical oncologists, and related experts. POR is supported by an acknowledged international advisory board and the Arányi Fundation for modern pathology.
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