脂质和脂蛋白。

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Danish medical journal Pub Date : 2023-06-26

Anders Berg Wulff, Børge G Nordestgaard

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引用次数: 0

摘要

脂类在人体生理中是必不可少的，甘油三酯提供能量，胆固醇是细胞的结构成分，是激素和维生素的前体。然而，血液中胆固醇水平高会导致动脉粥样硬化，导致心血管疾病，这是全球第一大死亡原因。遗传证据表明，脂蛋白(a)和残余胆固醇(极低密度和中密度脂蛋白中的胆固醇)与低密度脂蛋白一起与心血管疾病的发展有因果关系，这刺激了有效降低这些疾病的药物的开发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Lipids and lipoproteins.

Lipids are essential in human physiology, triglycerides for energy and cholesterol as a structural component in cells and as a precurser for hormones and vitamins. However, high blood levels of cholesterol cause atherosclerosis, leading to cardiovascular disease, which is the number one cause of death globally. Genetic evidence suggests that lipoprotein(a) and remnant cholesterol, cholesterol in very low-density and intermediate-density lipoproteins, are causally involved in the development of cardiovascular disease together with low-density lipoproteins and this has spurred the development of drugs potently lowering these.

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来源期刊

Danish medical journal MEDICINE, GENERAL & INTERNAL-

CiteScore

2.30

自引率

6.20%

发文量

审稿时长

3-8 weeks

期刊介绍： The Danish Medical Journal (DMJ) is a general medical journal. The journal publish original research in English – conducted in or in relation to the Danish health-care system. When writing for the Danish Medical Journal please remember target audience which is the general reader. This means that the research area should be relevant to many readers and the paper should be presented in a way that most readers will understand the content. DMJ will publish the following articles: • Original articles • Protocol articles from large randomized clinical trials • Systematic reviews and meta-analyses • PhD theses from Danish faculties of health sciences • DMSc theses from Danish faculties of health sciences.