可溶性尿躯体血管紧张素转换酶在先兆子痫患者中过度表达:该疾病的潜在新标志物?

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Hypertension in Pregnancy Pub Date : 2022-08-01 DOI:10.1080/10641955.2022.2115060

Fernando Sontag, Sonja Suvakov, Vesna D Garovic

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引用次数: 0

摘要

目的:探讨妊娠期高血压疾病患者尿血管紧张素转换酶(ACE)水平。方法:采用免疫印迹法对尿样进行分析。患者分为:正常妊娠(N);子痫前期和合并子痫前期(PE+SPE);妊娠期高血压(GH)。结果:PE+SPE组的ACE蛋白表达高于N和GH组。ACE与尿蛋白/肌酐比值、收缩压和舒张压呈正相关。结论:这些结果提示ACE在子痫前期患者尿液中过表达，提示它可能是该病的一个新的标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Soluble urinary somatic angiotensin converting enzyme is overexpressed in patients with preeclampsia: a potential new marker for the disease?

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Soluble urinary somatic angiotensin converting enzyme is overexpressed in patients with preeclampsia: a potential new marker for the disease?

Objective: The aim of this study was to identify and quantify urinary Angiotensin-Converting-Enzyme (ACE) in hypertensive disorders of pregnancy.

Methods: Urine samples were analyzed by Western blot. Patients were classified into: normotensive pregnancy (N); preeclampsia and superimposed preeclampsia (PE+SPE); and gestational hypertension (GH).

Results: Somatic ACE protein expression was higher in PE+SPE compared to N and GH. There was a positive correlation between ACE and urinary protein to creatinine ratio, systolic and diastolic blood pressures.

Conclusion: These results indicate ACE overexpression in the urine of preeclamptic patients and suggest that it may be a new marker for the disease.

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来源期刊

Hypertension in Pregnancy 医学-妇产科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.