慢性牙周炎患者口腔菌群、炎症因子及免疫功能指标的变化及其临床意义

IF 1.5 4区 医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Guodong Jia, Zhenhu Ren
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引用次数: 0

摘要

本研究旨在探讨慢性牙周炎(chronic periodontitis, CP)患者口腔菌群、炎症因子、免疫功能指标的变化及其临床意义。记录研究对象的牙龈指数(GI)、沟出血指数(SBI)等临床指标。测定研究对象龈沟液(GCF)中口腔菌群、炎症因子及T淋巴细胞亚群水平。为分析GI、牙龈SBI与口腔菌群、炎症因子、免疫功能指标的相关性,采用Pearson相关分析。牙龈卟啉单胞菌、消化链球菌、中间普氏菌、维诺球菌、肿瘤坏死因子α (TNF-α)、白细胞介素6 (IL-6)、IL-8、CD3+、CD4+、CD4+/CD8+与GI、SBI呈正相关,IL-10、CD8+与GI、SBI呈负相关。CP患者口腔菌群、炎症因子及免疫功能指标水平均显著升高,并与CP临床指标相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Changes of Oral Flora, Inflammatory Factors, and Immune Function Indicators in Patients with Chronic Periodontitis and Their Clinical Significance.

This research focuses on investigating the changes of oral flora, inflammatory factors, and immune function indicators in patients with chronic periodontitis (CP) and their clinical significances. Clinical indices such as gingival index (GI) and sulcus bleeding index (SBI) of the study subjects were recorded. The levels of oral flora, inflammatory factors and T lymphocyte subsets in gingival crevicular fluid (GCF) of the study subjects were measured. To analyze the correlation between GI and gingival SBI and oral flora, inflammatory factors, and immune function indicators, Pearson correlation analysis was performed. Porphyromonas gingivalis, Streptococcus digestiveis, Prevotella intermedia, Veronococcus, tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), IL-8, CD3+, CD4+, and CD4+/CD8+ had a positive correlation with GI and SBI, while IL-10 and CD8+ were negatively correlated with GI and SBI. Oral flora, inflammatory factors and immune function indicators levels are largely elevated in patients with CP and they are correlated with CP clinical indicators.

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来源期刊
Critical Reviews in Eukaryotic Gene Expression
Critical Reviews in Eukaryotic Gene Expression 生物-生物工程与应用微生物
CiteScore
2.70
自引率
0.00%
发文量
67
审稿时长
1 months
期刊介绍: Critical ReviewsTM in Eukaryotic Gene Expression presents timely concepts and experimental approaches that are contributing to rapid advances in our mechanistic understanding of gene regulation, organization, and structure within the contexts of biological control and the diagnosis/treatment of disease. The journal provides in-depth critical reviews, on well-defined topics of immediate interest, written by recognized specialists in the field. Extensive literature citations provide a comprehensive information resource. Reviews are developed from an historical perspective and suggest directions that can be anticipated. Strengths as well as limitations of methodologies and experimental strategies are considered.
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