SPART将自噬机制和运动神经元中的脂滴联系起来。

IF 14.6 1区生物学 Q1 CELL BIOLOGY

Autophagy Pub Date : 2023-11-01 Epub Date: 2023-08-22 DOI:10.1080/15548627.2023.2247311

Shree Padma Metur, Daniel J Klionsky

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引用次数: 0

摘要

自噬，以脂吞噬的形式，是一种重要的分解代谢途径，介导脂滴的降解和脂质为生理功能的动员。然而，将脂滴/LD与自噬机制联系起来的分子机制和蛋白质受体仍然未知。在这里，我们讨论了Chung等人最近的一项研究。该研究将SPART确定为脂滴自噬的受体，在运动神经元甘油三酯的转换中起着重要作用。

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SPART links autophagy machinery and lipid droplets in motor neurons.

Autophagy, in the form of lipophagy, is an important catabolic pathway mediating the degradation of lipid droplets and mobilization of lipids for physiological function. However, the molecular mechanism and the protein receptors that link lipid droplets/LDs to the autophagy machinery remain unknown. Here, we discuss a recent study by Chung et al. that identifies SPART as the receptor for autophagy of lipid droplets that plays an important role in the turnover of triglycerides in motor neurons.

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来源期刊

Autophagy 生物-细胞生物学

CiteScore

21.30

自引率

2.30%

发文量

277

审稿时长

1 months

期刊介绍： Autophagy is a peer-reviewed journal that publishes research on autophagic processes, including the lysosome/vacuole dependent degradation of intracellular material. It aims to be the premier journal in the field and covers various connections between autophagy and human health and disease, such as cancer, neurodegeneration, aging, diabetes, myopathies, and heart disease. Autophagy is interested in all experimental systems, from yeast to human. Suggestions for specialized topics are welcome. The journal accepts the following types of articles: Original research, Reviews, Technical papers, Brief Reports, Addenda, Letters to the Editor, Commentaries and Views, and Articles on science and art. Autophagy is abstracted/indexed in Adis International Ltd (Reactions Weekly), EBSCOhost (Biological Abstracts), Elsevier BV (EMBASE and Scopus), PubMed, Biological Abstracts, Science Citation Index Expanded, Web of Science, and MEDLINE.