{"title":"膜受体和配体的顺式半胱氨酸相互作用。","authors":"Enfu Hui","doi":"10.1146/annurev-cellbio-120420-103941","DOIUrl":null,"url":null,"abstract":"<p><p>Cell-cell communication is critical for the development and function of multicellular organisms. A crucial means by which cells communicate with one another is physical interactions between receptors on one cell and their ligands on a neighboring cell. <i>Trans</i> ligand:receptor interactions activate the receptor, ultimately leading to changes in the fate of the receptor-expressing cells. Such <i>trans</i> signaling is known to be critical for the functions of cells in the nervous and immune systems, among others. Historically, <i>trans</i> interactions are the primary conceptual framework for understanding cell-cell communication. However, cells often coexpress many receptors and ligands, and a subset of these has been reported to interact in <i>cis</i> and profoundly impact cell functions. <i>Cis</i> interactions likely constitute a fundamental, understudied regulatory mechanism in cell biology. Here, I discuss how <i>cis</i> interactions between membrane receptors and ligands regulate immune cell functions, and I also highlight outstanding questions in the field.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"391-408"},"PeriodicalIF":11.4000,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"<i>Cis</i> Interactions of Membrane Receptors and Ligands.\",\"authors\":\"Enfu Hui\",\"doi\":\"10.1146/annurev-cellbio-120420-103941\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Cell-cell communication is critical for the development and function of multicellular organisms. A crucial means by which cells communicate with one another is physical interactions between receptors on one cell and their ligands on a neighboring cell. <i>Trans</i> ligand:receptor interactions activate the receptor, ultimately leading to changes in the fate of the receptor-expressing cells. Such <i>trans</i> signaling is known to be critical for the functions of cells in the nervous and immune systems, among others. Historically, <i>trans</i> interactions are the primary conceptual framework for understanding cell-cell communication. However, cells often coexpress many receptors and ligands, and a subset of these has been reported to interact in <i>cis</i> and profoundly impact cell functions. <i>Cis</i> interactions likely constitute a fundamental, understudied regulatory mechanism in cell biology. Here, I discuss how <i>cis</i> interactions between membrane receptors and ligands regulate immune cell functions, and I also highlight outstanding questions in the field.</p>\",\"PeriodicalId\":7944,\"journal\":{\"name\":\"Annual review of cell and developmental biology\",\"volume\":\" \",\"pages\":\"391-408\"},\"PeriodicalIF\":11.4000,\"publicationDate\":\"2023-10-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annual review of cell and developmental biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1146/annurev-cellbio-120420-103941\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/6/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual review of cell and developmental biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1146/annurev-cellbio-120420-103941","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/6/20 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Cis Interactions of Membrane Receptors and Ligands.
Cell-cell communication is critical for the development and function of multicellular organisms. A crucial means by which cells communicate with one another is physical interactions between receptors on one cell and their ligands on a neighboring cell. Trans ligand:receptor interactions activate the receptor, ultimately leading to changes in the fate of the receptor-expressing cells. Such trans signaling is known to be critical for the functions of cells in the nervous and immune systems, among others. Historically, trans interactions are the primary conceptual framework for understanding cell-cell communication. However, cells often coexpress many receptors and ligands, and a subset of these has been reported to interact in cis and profoundly impact cell functions. Cis interactions likely constitute a fundamental, understudied regulatory mechanism in cell biology. Here, I discuss how cis interactions between membrane receptors and ligands regulate immune cell functions, and I also highlight outstanding questions in the field.
期刊介绍:
The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.