膜受体和配体的顺式半胱氨酸相互作用。

IF 11.4 1区 生物学 Q1 CELL BIOLOGY
Enfu Hui
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引用次数: 0

摘要

细胞间通讯对多细胞生物的发育和功能至关重要。细胞相互交流的一个关键手段是一个细胞上的受体和相邻细胞上的配体之间的物理相互作用。反式配体:受体相互作用激活受体,最终导致受体表达细胞命运的改变。众所周知,这种反式信号传导对神经和免疫系统中细胞的功能至关重要。从历史上看,跨体相互作用是理解细胞间通信的主要概念框架。然而,细胞通常共表达许多受体和配体,据报道,其中一个子集以顺式相互作用,并深刻影响细胞功能。Cis相互作用可能构成细胞生物学中一种基本的、研究不足的调节机制。在这里,我讨论了膜受体和配体之间的顺式相互作用如何调节免疫细胞功能,我还强调了该领域悬而未决的问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cis Interactions of Membrane Receptors and Ligands.

Cell-cell communication is critical for the development and function of multicellular organisms. A crucial means by which cells communicate with one another is physical interactions between receptors on one cell and their ligands on a neighboring cell. Trans ligand:receptor interactions activate the receptor, ultimately leading to changes in the fate of the receptor-expressing cells. Such trans signaling is known to be critical for the functions of cells in the nervous and immune systems, among others. Historically, trans interactions are the primary conceptual framework for understanding cell-cell communication. However, cells often coexpress many receptors and ligands, and a subset of these has been reported to interact in cis and profoundly impact cell functions. Cis interactions likely constitute a fundamental, understudied regulatory mechanism in cell biology. Here, I discuss how cis interactions between membrane receptors and ligands regulate immune cell functions, and I also highlight outstanding questions in the field.

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来源期刊
CiteScore
19.50
自引率
0.00%
发文量
21
期刊介绍: The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.
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