用17α-甲基睾酮诱导斑马鱼种群雄性化的简单方法

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-12-01 Epub Date: 2022-11-01 DOI:10.1089/zeb.2022.0029

Jennifer L Matthews, Joy Murphy, Andrzej Nasiadka, Zoltan M Varga

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引用次数: 2

摘要

斑马鱼种群的性别比例严重失衡，可能对种群繁殖和精子冷冻保存造成重大障碍。为了克服从进口精子样本中获得的种群性别比例偏雌的问题，斑马鱼国际资源中心在幼虫食物中添加了17α-甲基睾酮，以使性腺性别分化向雄性化倾斜。由此产生的种群平均80%为雄性。

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A Simple Method for Inducing Masculinization of Zebrafish Stocks Using 17α-Methyltestosterone.

Severely skewed sex ratios in zebrafish stocks can pose significant hurdles for line propagation and sperm cryopreservation. To overcome female-biased sex ratios in stocks derived from imported sperm samples, the Zebrafish International Resource Center has implemented routine supplementation of larval food with 17α-methyltestosterone to skew gonadal sex differentiation toward masculinization. Resulting stocks averaged 80% males.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.