抗原处理机制在细胞内Toll样受体分子的调节和运输中的作用。

IF 6.6 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2023-10-01 DOI:10.1016/j.coi.2023.102375

Moïse de Lavergne, Lucie Maisonneuve, Katrina Podsypanina, Bénédicte Manoury

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引用次数: 0

摘要

细胞内Toll样受体（TLRs）是先天免疫系统的关键组成部分。它们在抗原呈递细胞（APC），特别是树突状细胞（DC）中的表达，使其在诱导适应性免疫反应中发挥关键作用。在DC中，它们与伴侣UNC93B1相互作用，后者介导它们从内质网（ER）运输到内涵体，在那里它们被蛋白酶切割并激活。所有这些不同的步骤也被主要的组织相容性复合体II类（MHCII）分子共享。在这里，我们将讨论细胞内TLR与APC中的抗原处理机制在其运输和激活方面的紧密关系。

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The role of the antigen processing machinery in the regulation and trafficking of intracellular -Toll-like receptor molecules

Intracellular Toll-like receptors (TLRs) are key components of the innate immune system. Their expression in antigen-presenting cells (APCs), and in particular dendritic cells (DCs), makes them critical in the induction of the adaptive immune response. In DCs, they interact with the chaperone UNC93B1 that mediates their trafficking from the endoplasmic reticulum (ER) to endosomes where they are cleaved by proteases and activated. All these different steps are also shared by major histocompatibility complex class-II (MHCII) molecules. Here, we will discuss the tight relationship intracellular TLRs have with the antigen processing machinery in APCs for their trafficking and activation.

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来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

期刊介绍： Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.