MiR-96-5p参与了乳腺癌症细胞的渗透促进增殖和迁移。

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Acta biochimica Polonica Pub Date : 2023-08-17 DOI:10.18388/abp.2020_6533

Yi Yan, Tian Wen Long, Xi Niu, Jia Fu Wang, Sheng Li

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引用次数: 0

摘要

微小RNA（miRNA）是细胞对外源性化合物和毒素反应的主要参与者。然而，miRNA在拟除虫菊酯类农药诱导的癌症进展中的作用仍不清楚。本研究旨在研究miR-96-5p在透丝菌素诱导的癌症细胞增殖和迁移中的作用。在我们的研究中，miR-96-5p在氯氰菊酯处理的MCF-7细胞中的表达上调。MiR-96-5p促进MCF-7细胞增殖和迁移，同时改变参与细胞增殖、迁移和凋亡的蛋白质的表达。同源盒A5（HOXA5）被鉴定为miR-96-5p的直接靶标。HOXA5的沉默与miR-96-5p的抑制作用相反。总之，这些结果表明miR-96-5p通过靶向HOXA5参与了乳腺癌症细胞的透thrin促进的增殖和迁移。

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MiR-96-5p is involved in permethrin-promoted proliferation and migration of breast cancer cells.

MicroRNAs (miRNAs) are major players in cellular responses to xenobiotic compounds and toxins. However, the role of miRNAs in pyrethroid pesticide-induced cancer progression remains unclear. This study aimed to investigate the function of miR-96-5p in permethrin-induced proliferation and migration in breast cancer cells. In our study, the expression of miR-96-5p was upregulated in permethrin-treated MCF-7 cells. MiR-96-5p promoted MCF-7 cell proliferation and migration, accompanied bychanges in the expression of proteins involved in cell proliferation, migration, and apoptosis. Homeobox A5 (HOXA5) was identified as a direct target of miR-96-5p. HOXA5 silencing had the opposite effects with miR-96-5p inhibition. In conclusion, these results suggest that miR-96-5p is involved in permethrin-promoted proliferation and migration of breast cancer cells by targeting HOXA5.

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来源期刊

Acta biochimica Polonica 生物-生化与分子生物学

CiteScore

2.40

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Acta Biochimica Polonica is a journal covering enzymology and metabolism, membranes and bioenergetics, gene structure and expression, protein, nucleic acid and carbohydrate structure and metabolism.