从噬菌体-哺乳动物相互作用的角度提高噬菌体治疗的安全性和有效性。

IF 10.1 2区 生物学 Q1 MICROBIOLOGY
Geng Zou, Lijun He, Jing Rao, Zhiyong Song, Hu Du, Runze Li, Wenjing Wang, Yang Zhou, Lu Liang, Huanchun Chen, Jinquan Li
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引用次数: 1

摘要

噬菌体治疗已重新出现作为一个有希望的解决方案,以对抗抗菌素耐药细菌感染。越来越多的研究表明,噬菌体除了具有抗菌特性外,还具有治疗潜力,包括调节肠道微生物群和维持肠道稳态,作为靶向药物递送的新型纳米载体。然而,治疗过程中噬菌体行为的复杂性和不可预测性给临床实践带来了重大挑战。噬菌体、人类和细菌在自然生态系统中长期共存,它们之间建立了复杂的相互作用,这导致了噬菌体治疗行为的复杂性,引起了人们对其作为治疗剂的有效性和安全性的关注。揭示噬菌体与人体相互作用的机制将为噬菌体治疗的进一步应用提供理论基础。在这篇综述中,我们全面总结了噬菌体与哺乳动物的相互作用,包括信号通路、适应性免疫反应和噬菌体介导的抗炎反应。然后,从噬菌体-哺乳动物免疫系统相互作用的角度,首次系统综述了影响噬菌体治疗的因素,如给药方式、患者的生理状态、噬菌体的生物学特性等,为噬菌体治疗各种人类疾病提供新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Improving the safety and efficacy of phage therapy from the perspective of phage-mammal interactions.

Phage therapy has re-emerged as a promising solution for combating antimicrobial-resistant bacterial infections. Increasingly, studies have revealed that phages possess therapeutic potential beyond their antimicrobial properties, including regulating the gut microbiome and maintain intestinal homeostasis, as a novel nanocarrier for targeted drug delivery. However, the complexity and unpredictability of phage behavior during treatment pose a significant challenge in clinical practice. The intricate interactions established between phages, humans, and bacteria throughout their long coexistence in the natural ecosystem contribute to the complexity of phage behavior in therapy, raising concerns about their efficacy and safety as therapeutic agents. Revealing the mechanisms by which phages interact with the human body will provide a theoretical basis for increased application of promising phage therapy. In this review, we provide a comprehensive summary of phage-mammal interactions, including signaling pathways, adaptive immunity responses, and phage-mediated anti-inflammatory responses. Then, from the perspective of phage-mammalian immune system interactions, we present the first systematic overview of the factors affecting phage therapy, such as the mode of administration, the physiological status of the patient, and the biological properties of the phage, to offer new insights into phage therapy for various human diseases.

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来源期刊
FEMS microbiology reviews
FEMS microbiology reviews 生物-微生物学
CiteScore
17.50
自引率
0.90%
发文量
45
审稿时长
6-12 weeks
期刊介绍: Title: FEMS Microbiology Reviews Journal Focus: Publishes reviews covering all aspects of microbiology not recently surveyed Reviews topics of current interest Provides comprehensive, critical, and authoritative coverage Offers new perspectives and critical, detailed discussions of significant trends May contain speculative and selective elements Aimed at both specialists and general readers Reviews should be framed within the context of general microbiology and biology Submission Criteria: Manuscripts should not be unevaluated compilations of literature Lectures delivered at symposia must review the related field to be acceptable
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