【ACSL3在动脉粥样硬化中的作用研究进展】。

Q3 Medicine

生理学报 Pub Date : 2023-08-25

Li Yang, Zhong-Hua Yuan

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引用次数: 0

摘要

脂滴是储存中性脂质的细胞器，与脂质积累密切相关。长链酰基辅酶A合成酶3 (Long chain酰基辅酶A合成酶3,ACSL3)是一种脂滴相关蛋白，主要分布于细胞膜、内质网和细胞内脂滴，其分布与细胞类型和脂肪酸供应有关。ACSL3是脂肪酸代谢的关键调控因子，与细胞内脂质积累密切相关，在脂滴合成与脂质代谢、细胞炎症、铁下沉等多种病理生理过程中发挥重要作用。本文主要综述ACSL3在脂质合成、铁下沉和炎症反应中的作用，重点探讨其在动脉粥样硬化中脂质积累的作用机制，为探索动脉粥样硬化疾病的潜在治疗靶点提供新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

[Research advances on the role of ACSL3 in the atherosclerosis].

Lipids droplets are organelles that store neutral lipids and are closely related to lipid accumulation. Long chain acyl-coenzyme A synthetase 3 (ACSL3) is a lipid droplet-associated protein mainly distributed in the cell membrane, endoplasmic reticulum, and intracellular lipid droplets, and its distribution depends on cell type and fatty acid supply. ACSL3 is a key regulator of fatty acid metabolism that is closely related to intracellular lipid accumulation, and plays an important role in various pathophysiological processes such as lipid droplet synthesis and lipid metabolism, cellular inflammation, and ferroptosis. This paper mainly reviews the role of ACSL3 in lipid synthesis, ferroptosis, and inflammatory response, with focus on the mechanism of its role in lipid accumulation in atherosclerosis, and provides new ideas for exploring potential therapeutic targets in atherosclerotic diseases.

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来源期刊

生理学报 Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

4820

期刊介绍： Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.