干眼症患者的干眼症状和体征之间的关联。

IF 1.7 4区 医学 Q3 OPHTHALMOLOGY
Ophthalmic epidemiology Pub Date : 2024-06-01 Epub Date: 2023-08-17 DOI:10.1080/09286586.2023.2248629
Andrew Tawfik, Maxwell Pistilli, Maureen G Maguire, Yineng Chen, Yinxi Yu, Jack V Greiner, Penny A Asbell, Gui-Shuang Ying
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引用次数: 0

摘要

目的:在干眼症评估和管理(DREAM)研究中确定干眼症(DED)症状和体征之间的相关性:共有 535 名中重度 DED 患者在基线和随访(第 3、6 和 12 个月)时按照标准化方案接受了眼表疾病指数 (OSDI) 和四种双眼 DED 征象(结膜利萨明绿染色、角膜荧光素染色、Schirmer 测试和泪液破裂时间 (TBUT))的症状评估。计算了基线时 DED 症状和体征之间的相关性以及 12 个月时症状和体征与基线相比的变化的斯皮尔曼相关系数 (rho)。相关系数的置信区间和 p 值采用群组引导法计算,以考虑眼间相关性:基线时,OSDI 总分与体征无关;但 OSDI 眼部症状分量表得分与角膜染色得分(rho = 0.14,p = .002)和 Schirmer 测试得分(rho = 0.11,p = .01)呈弱相关。四种体征之间存在统计学意义上的相关性(p 结论:这四种体征之间存在统计学意义上的相关性:与之前的研究一致,在基线值为中度至重度 DED 的 DREAM 参与者中,DED 症状与体征的相关性较低,四种客观体征之间的相关性为低度至中度。症状和体征变化之间的相关性更弱。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of Dry Eye Symptoms and Signs in Patients with Dry Eye Disease.

Purpose: To determine the correlations among symptoms and signs of dry eye disease (DED) in the Dry Eye Assessment and Management (DREAM) study.

Methods: A total of 535 patients with moderate-to-severe DED were assessed for symptoms using the Ocular Surface Disease Index (OSDI) and four DED signs in both eyes (conjunctival lissamine green staining, corneal fluorescein staining, Schirmer's testing, and tear break-up time (TBUT)) following standardized protocols at baseline and follow-up visits (months 3, 6, and 12). Spearman correlation coefficients (rho) were calculated for correlations among symptoms and signs of DED at baseline and among changes in symptoms and signs from baseline at 12 months. The confidence intervals and p-values for correlation coefficients were calculated using a cluster bootstrapping to account for inter-eye correlation.

Results: At baseline, OSDI total score was not correlated with signs; however, OSDI subscale score of ocular symptoms was weakly correlated with corneal staining score (rho = 0.14, p = .002) and Schirmer test score (rho = 0.11, p = .01). There were statistically significant correlations among the four signs (p < .001), with absolute correlation coefficient ranging from 0.14 (conjunctival staining score vs. TBUT) to 0.33 (conjunctival staining score vs. cornea staining score). The correlations among changes in symptoms and signs were weaker, with the highest correlation between change in conjunctival staining and corneal staining (rho = 0.21, p < .001).

Conclusions: Consistent with previous studies, among DREAM participants with moderate-to-severe DED at baseline, correlations of DED symptoms with signs were low and correlations among four objective signs were low to moderate. The correlations among changes in symptoms and signs were even weaker.

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来源期刊
Ophthalmic epidemiology
Ophthalmic epidemiology 医学-眼科学
CiteScore
3.70
自引率
5.60%
发文量
61
审稿时长
6-12 weeks
期刊介绍: Ophthalmic Epidemiology is dedicated to the publication of original research into eye and vision health in the fields of epidemiology, public health and the prevention of blindness. Ophthalmic Epidemiology publishes editorials, original research reports, systematic reviews and meta-analysis articles, brief communications and letters to the editor on all subjects related to ophthalmic epidemiology. A broad range of topics is suitable, such as: evaluating the risk of ocular diseases, general and specific study designs, screening program implementation and evaluation, eye health care access, delivery and outcomes, therapeutic efficacy or effectiveness, disease prognosis and quality of life, cost-benefit analysis, biostatistical theory and risk factor analysis. We are looking to expand our engagement with reports of international interest, including those regarding problems affecting developing countries, although reports from all over the world potentially are suitable. Clinical case reports, small case series (not enough for a cohort analysis) articles and animal research reports are not appropriate for this journal.
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