Moyamoya 病间接血管再通术后侧支循环形成的影响因素:叙述性综述。

IF 3.8 2区 医学 Q1 CLINICAL NEUROLOGY
Translational Stroke Research Pub Date : 2024-12-01 Epub Date: 2023-08-17 DOI:10.1007/s12975-023-01185-x
Gan Gao, Si-Meng Liu, Fang-Bin Hao, Qian-Nan Wang, Xiao-Peng Wang, Min-Jie Wang, Xiang-Yang Bao, Cong Han, Lian Duan
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引用次数: 0

摘要

间接血管再通是治疗 Moyamoya 病的主要技术之一。良好侧支循环的形成是改善脑血流灌注、降低继发性脑卒中风险的关键措施,也是评价间接血管再通效果的主要方法。因此,如何在手术前后预测并促进侧支循环的形成,对提高 Moyamoya 病间接血管再通的成功率具有重要意义。先前的研究表明,在 Moyamoya 病患者身上观察到的血管内皮生长因子、内皮祖细胞、Caveolin-1 和其他因子可能在间接血管再通术后通过内皮增生和平滑肌迁移生成侧支血管的过程中发挥关键作用。此外,遗传因子 RNF213 的突变也与这一过程有关。本研究总结了影响 Moyamoya 病间接血管再通后侧支循环形成的因素和机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Factors Influencing Collateral Circulation Formation After Indirect Revascularization for Moyamoya Disease: a Narrative Review.

Indirect revascularization is one of the main techniques for the treatment of Moyamoya disease. The formation of good collateral circulation is a key measure to improve cerebral blood perfusion and reduce the risk of secondary stroke, and is the main method for evaluating the effect of indirect revascularization. Therefore, how to predict and promote the formation of collateral circulation before and after surgery is important for improving the success rate of indirect revascularization in Moyamoya disease. Previous studies have shown that vascular endothelial growth factor, endothelial progenitor cells, Caveolin-1, and other factors observed in patients with Moyamoya disease may play a key role in the generation of collateral vessels after indirect revascularization through endothelial hyperplasia and smooth muscle migration. In addition, mutations in the genetic factor RNF213 have also been associated with this process. This study summarizes the factors and mechanisms influencing collateral circulation formation after indirect revascularization in Moyamoya disease.

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来源期刊
Translational Stroke Research
Translational Stroke Research CLINICAL NEUROLOGY-NEUROSCIENCES
CiteScore
13.80
自引率
4.30%
发文量
130
审稿时长
6-12 weeks
期刊介绍: Translational Stroke Research covers basic, translational, and clinical studies. The Journal emphasizes novel approaches to help both to understand clinical phenomenon through basic science tools, and to translate basic science discoveries into the development of new strategies for the prevention, assessment, treatment, and enhancement of central nervous system repair after stroke and other forms of neurotrauma. Translational Stroke Research focuses on translational research and is relevant to both basic scientists and physicians, including but not restricted to neuroscientists, vascular biologists, neurologists, neuroimagers, and neurosurgeons.
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